Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
SYK	BLNK	Tyr84	EHSDSEMyVMPAEEN	phosphorylation up-regulates	12456653	SIGNOR-96048
SYK	BLNK	Tyr72	SDDFDSDyENPDEHS	phosphorylation up-regulates	12456653	SIGNOR-96044
SH2B1	BLNK	–		dephosphorylation down-regulates activity	32323266	SIGNOR-268446
SYK	BLNK	Tyr178	LLEDEADyVVPVEDN	phosphorylation up-regulates	12456653	SIGNOR-96040
SYK	BLNK	Tyr96	EENADDSyEPPPVEQ	phosphorylation up-regulates	12456653	SIGNOR-96052
PTPRG	BLNK	Tyr84	EHSDSEMyVMPAEEN	dephosphorylation up-regulates activity	25624455	SIGNOR-254692

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
SYK	phosphorylation up-regulates →	BLNK PTyr84	phosphorylation up-regulates →	BLNK	12456653	SIGNOR-96048
SYK	phosphorylation up-regulates →	BLNK PTyr72	phosphorylation up-regulates →	BLNK	12456653	SIGNOR-96044
SYK	phosphorylation up-regulates →	BLNK PTyr178	phosphorylation up-regulates →	BLNK	12456653	SIGNOR-96040
SYK	phosphorylation up-regulates →	BLNK PTyr96	phosphorylation up-regulates →	BLNK	12456653	SIGNOR-96052
PTPRG	dephosphorylation down-regulates ⊣	BLNK PTyr84	dephosphorylation down-regulates ⊣	BLNK	25624455	SIGNOR-254692

Regulator	Mechanism/Effect	Target	SIGNOR-ID
SYK	phosphorylation → up-regulates	BLNK	SIGNOR-96048
SYK	phosphorylation → up-regulates	BLNK	SIGNOR-96044
SH2B1	dephosphorylation → down-regulates activity	BLNK	SIGNOR-268446
SYK	phosphorylation → up-regulates	BLNK	SIGNOR-96040
SYK	phosphorylation → up-regulates	BLNK	SIGNOR-96052
PTPRG	dephosphorylation → up-regulates activity	BLNK	SIGNOR-254692