| Name | PPM1E |
| ID | Q8WY54 |
| Role | phosphatase |
| Enzymatic Domains |
PPM-type phosphatase 231-488 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1E | PAK1 | Ser57 | KKDRFYRsILPGDKT | dephosphorylation down-regulates activity | 11864573 | SIGNOR-248760 |
| PPM1E | PAK1 | Thr423 | PEQSKRStMVGTPYW | dephosphorylation down-regulates activity | 11864573 | SIGNOR-248761 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1E | dephosphorylation down-regulates ⊣ | PAK1 PSer57 | dephosphorylation up-regulates → | PAK1 | 11864573 | SIGNOR-248760 |
| PPM1E | dephosphorylation down-regulates ⊣ | PAK1 PThr423 | dephosphorylation up-regulates → | PAK1 | 11864573 | SIGNOR-248761 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPM1E | dephosphorylation → down-regulates activity | PAK1 | SIGNOR-248760 |
| PPM1E | dephosphorylation → down-regulates activity | PAK1 | SIGNOR-248761 |