| Name | SHC3 |
| ID | Q92529-2 |
| Role | substrate |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| NTRK2 | SHC3 | Tyr219 | DGSDHPYyNSIPSKM | phosphorylation up-regulates activity | 11791173 | SIGNOR-273918 |
| EGFR | SHC3 | Tyr219 | DGSDHPYyNSIPSKM | phosphorylation up-regulates activity | 11791173 | SIGNOR-273912 |
| SRC | SHC3 | Tyr283 | RQGSSDIySTPEGKL | phosphorylation up-regulates activity | 11791173 | SIGNOR-273920 |
| NTRK2 | SHC3 | Tyr301 | PTGEAPTyVNTQQIP | phosphorylation up-regulates activity | 11791173 | SIGNOR-273924 |
| SRC | SHC3 | Tyr301 | PTGEAPTyVNTQQIP | phosphorylation up-regulates activity | 11791173 | SIGNOR-273925 |
| NTRK2 | SHC3 | Tyr283 | RQGSSDIySTPEGKL | phosphorylation up-regulates activity | 11791173 | SIGNOR-273917 |
| EGFR | SHC3 | Tyr301 | PTGEAPTyVNTQQIP | phosphorylation up-regulates activity | 11791173 | SIGNOR-273922 |
| NTRK1 | SHC3 | Tyr218 | GDGSDHPyYNSIPSK | phosphorylation up-regulates activity | 11791173 | SIGNOR-273913 |
| SRC | SHC3 | Tyr218 | GDGSDHPyYNSIPSK | phosphorylation up-regulates activity | 11791173 | SIGNOR-273919 |
| EGFR | SHC3 | Tyr218 | GDGSDHPyYNSIPSK | phosphorylation up-regulates activity | 11791173 | SIGNOR-273910 |
| NTRK1 | SHC3 | Tyr219 | DGSDHPYyNSIPSKM | phosphorylation up-regulates activity | 11791173 | SIGNOR-273915 |
| SRC | SHC3 | Tyr219 | DGSDHPYyNSIPSKM | phosphorylation up-regulates activity | 11791173 | SIGNOR-273921 |
| NTRK2 | SHC3 | Tyr218 | GDGSDHPyYNSIPSK | phosphorylation up-regulates activity | 11791173 | SIGNOR-273916 |
| EGFR | SHC3 | Tyr283 | RQGSSDIySTPEGKL | phosphorylation up-regulates activity | 11791173 | SIGNOR-273911 |
| NTRK1 | SHC3 | Tyr283 | RQGSSDIySTPEGKL | phosphorylation up-regulates activity | 11791173 | SIGNOR-273914 |
| NTRK1 | SHC3 | Tyr301 | PTGEAPTyVNTQQIP | phosphorylation up-regulates activity | 11791173 | SIGNOR-273923 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| NTRK2 | phosphorylation up-regulates → | SHC3 PTyr219 | phosphorylation up-regulates → | SHC3 | 11791173 | SIGNOR-273918 |
| EGFR | phosphorylation up-regulates → | SHC3 PTyr219 | phosphorylation up-regulates → | SHC3 | 11791173 | SIGNOR-273912 |
| SRC | phosphorylation up-regulates → | SHC3 PTyr283 | phosphorylation up-regulates → | SHC3 | 11791173 | SIGNOR-273920 |
| NTRK2 | phosphorylation up-regulates → | SHC3 PTyr301 | phosphorylation up-regulates → | SHC3 | 11791173 | SIGNOR-273924 |
| SRC | phosphorylation up-regulates → | SHC3 PTyr301 | phosphorylation up-regulates → | SHC3 | 11791173 | SIGNOR-273925 |
| NTRK2 | phosphorylation up-regulates → | SHC3 PTyr283 | phosphorylation up-regulates → | SHC3 | 11791173 | SIGNOR-273917 |
| EGFR | phosphorylation up-regulates → | SHC3 PTyr301 | phosphorylation up-regulates → | SHC3 | 11791173 | SIGNOR-273922 |
| NTRK1 | phosphorylation up-regulates → | SHC3 PTyr218 | phosphorylation up-regulates → | SHC3 | 11791173 | SIGNOR-273913 |
| SRC | phosphorylation up-regulates → | SHC3 PTyr218 | phosphorylation up-regulates → | SHC3 | 11791173 | SIGNOR-273919 |
| EGFR | phosphorylation up-regulates → | SHC3 PTyr218 | phosphorylation up-regulates → | SHC3 | 11791173 | SIGNOR-273910 |
| NTRK1 | phosphorylation up-regulates → | SHC3 PTyr219 | phosphorylation up-regulates → | SHC3 | 11791173 | SIGNOR-273915 |
| SRC | phosphorylation up-regulates → | SHC3 PTyr219 | phosphorylation up-regulates → | SHC3 | 11791173 | SIGNOR-273921 |
| NTRK2 | phosphorylation up-regulates → | SHC3 PTyr218 | phosphorylation up-regulates → | SHC3 | 11791173 | SIGNOR-273916 |
| EGFR | phosphorylation up-regulates → | SHC3 PTyr283 | phosphorylation up-regulates → | SHC3 | 11791173 | SIGNOR-273911 |
| NTRK1 | phosphorylation up-regulates → | SHC3 PTyr283 | phosphorylation up-regulates → | SHC3 | 11791173 | SIGNOR-273914 |
| NTRK1 | phosphorylation up-regulates → | SHC3 PTyr301 | phosphorylation up-regulates → | SHC3 | 11791173 | SIGNOR-273923 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| NTRK2 | phosphorylation → up-regulates activity | SHC3 | SIGNOR-273918 |
| EGFR | phosphorylation → up-regulates activity | SHC3 | SIGNOR-273912 |
| SRC | phosphorylation → up-regulates activity | SHC3 | SIGNOR-273920 |
| NTRK2 | phosphorylation → up-regulates activity | SHC3 | SIGNOR-273924 |
| SRC | phosphorylation → up-regulates activity | SHC3 | SIGNOR-273925 |
| NTRK2 | phosphorylation → up-regulates activity | SHC3 | SIGNOR-273917 |
| EGFR | phosphorylation → up-regulates activity | SHC3 | SIGNOR-273922 |
| NTRK1 | phosphorylation → up-regulates activity | SHC3 | SIGNOR-273913 |
| SRC | phosphorylation → up-regulates activity | SHC3 | SIGNOR-273919 |
| EGFR | phosphorylation → up-regulates activity | SHC3 | SIGNOR-273910 |
| NTRK1 | phosphorylation → up-regulates activity | SHC3 | SIGNOR-273915 |
| SRC | phosphorylation → up-regulates activity | SHC3 | SIGNOR-273921 |
| NTRK2 | phosphorylation → up-regulates activity | SHC3 | SIGNOR-273916 |
| EGFR | phosphorylation → up-regulates activity | SHC3 | SIGNOR-273911 |
| NTRK1 | phosphorylation → up-regulates activity | SHC3 | SIGNOR-273914 |
| NTRK1 | phosphorylation → up-regulates activity | SHC3 | SIGNOR-273923 |