Entity Details

Name EGFR_Tyr218
ID Q92529-2
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
EGFRSHC3Tyr218GDGSDHPyYNSIPSKphosphorylation
up-regulates activity		11791173SIGNOR-273910
NTRK1SHC3Tyr218GDGSDHPyYNSIPSKphosphorylation
up-regulates activity		11791173SIGNOR-273913
SRCSHC3Tyr218GDGSDHPyYNSIPSKphosphorylation
up-regulates activity		11791173SIGNOR-273919
NTRK2SHC3Tyr218GDGSDHPyYNSIPSKphosphorylation
up-regulates activity		11791173SIGNOR-273916
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
EGFRphosphorylation
up-regulates
→
SHC3
PTyr218		phosphorylation
up-regulates
→		SHC311791173SIGNOR-273910
NTRK1phosphorylation
up-regulates
→
SHC3
PTyr218		phosphorylation
up-regulates
→		SHC311791173SIGNOR-273913
SRCphosphorylation
up-regulates
→
SHC3
PTyr218		phosphorylation
up-regulates
→		SHC311791173SIGNOR-273919
NTRK2phosphorylation
up-regulates
→
SHC3
PTyr218		phosphorylation
up-regulates
→		SHC311791173SIGNOR-273916
Regulator Mechanism/Effect Target SIGNOR-ID
EGFRphosphorylation
→
up-regulates activity 		SHC3SIGNOR-273910
NTRK1phosphorylation
→
up-regulates activity 		SHC3SIGNOR-273913
SRCphosphorylation
→
up-regulates activity 		SHC3SIGNOR-273919
NTRK2phosphorylation
→
up-regulates activity 		SHC3SIGNOR-273916