Entity Details

Name EGFR_Tyr283
ID Q92529-2
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
NTRK2SHC3Tyr283RQGSSDIySTPEGKLphosphorylation
up-regulates activity		11791173SIGNOR-273917
EGFRSHC3Tyr283RQGSSDIySTPEGKLphosphorylation
up-regulates activity		11791173SIGNOR-273911
NTRK1SHC3Tyr283RQGSSDIySTPEGKLphosphorylation
up-regulates activity		11791173SIGNOR-273914
SRCSHC3Tyr283RQGSSDIySTPEGKLphosphorylation
up-regulates activity		11791173SIGNOR-273920
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
NTRK2phosphorylation
up-regulates
→
SHC3
PTyr283		phosphorylation
up-regulates
→		SHC311791173SIGNOR-273917
EGFRphosphorylation
up-regulates
→
SHC3
PTyr283		phosphorylation
up-regulates
→		SHC311791173SIGNOR-273911
NTRK1phosphorylation
up-regulates
→
SHC3
PTyr283		phosphorylation
up-regulates
→		SHC311791173SIGNOR-273914
SRCphosphorylation
up-regulates
→
SHC3
PTyr283		phosphorylation
up-regulates
→		SHC311791173SIGNOR-273920
Regulator Mechanism/Effect Target SIGNOR-ID
NTRK2phosphorylation
→
up-regulates activity 		SHC3SIGNOR-273917
EGFRphosphorylation
→
up-regulates activity 		SHC3SIGNOR-273911
NTRK1phosphorylation
→
up-regulates activity 		SHC3SIGNOR-273914
SRCphosphorylation
→
up-regulates activity 		SHC3SIGNOR-273920