| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AMPK | TSC1 | – | phosphorylation up-regulates | 19584320 | SIGNOR-216487 | |
| MAPK1 | TSC1 | – | phosphorylation down-regulates | 15851026 | SIGNOR-135692 | |
| IKBKB | TSC1 | Ser511 | DSPFYRDsLPGSQRK | phosphorylation down-regulates | 17693255 | SIGNOR-157300 |
| PRKAA2 | TSC1 | – | phosphorylation up-regulates | 14651849 | SIGNOR-119541 | |
| ERK1/2 | TSC1 | – | phosphorylation down-regulates | 15851026 | SIGNOR-244761 | |
| CDK1 | TSC1 | Thr417 | SLPQATVtPPRKEER | phosphorylation unknown | 14551205 | SIGNOR-86696 |
| PLK1 | TSC1 | – | phosphorylation down-regulates quantity by destabilization | 36520312 | SIGNOR-280072 | |
| AMPK | TSC1 | – | phosphorylation up-regulates | 14651849 | SIGNOR-216441 | |
| CDK1 | TSC1 | Ser584 | ETSIFTPsPCKIPPP | phosphorylation unknown | 14551205 | SIGNOR-118588 |
| IKBKB | TSC1 | Ser511 | DSPFYRDsLPGSQRK | phosphorylation down-regulates | 19188143 | SIGNOR-183692 |
| CyclinB/CDK1 | TSC1 | Thr1047 | SSSSELStPEKPPHQ | phosphorylation down-regulates | 14551205 | SIGNOR-216949 |
| MAPK1 | TSC1 | – | phosphorylation down-regulates | 17671177 | SIGNOR-157162 | |
| CDK1 | TSC1 | Thr1047 | SSSSELStPEKPPHQ | phosphorylation unknown | 14551205 | SIGNOR-117339 |
| CDK1 | TSC1 | Thr417 | SLPQATVtPPRKEER | phosphorylation down-regulates | 14551205 | SIGNOR-118584 |
| IKBKB | TSC1 | Ser487 | AAISRELsEITTAEA | phosphorylation down-regulates | 17693255 | SIGNOR-157296 |
| CDK1 | TSC1 | Thr1047 | SSSSELStPEKPPHQ | phosphorylation down-regulates | 14551205 | SIGNOR-118580 |
| CyclinB/CDK1 | TSC1 | Ser584 | ETSIFTPsPCKIPPP | phosphorylation down-regulates | 14551205 | SIGNOR-216944 |
| CDK1 | TSC1 | Ser584 | ETSIFTPsPCKIPPP | phosphorylation down-regulates | 14551205 | SIGNOR-118576 |
| IKBKB | TSC1 | Ser487 | AAISRELsEITTAEA | phosphorylation down-regulates | 19188143 | SIGNOR-183688 |
| CyclinB/CDK1 | TSC1 | Thr417 | SLPQATVtPPRKEER | phosphorylation down-regulates | 14551205 | SIGNOR-216953 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| IKBKB | phosphorylation up-regulates → | TSC1 PSer511 | phosphorylation down-regulates ⊣ | TSC1 | 17693255 | SIGNOR-157300 |
| CDK1 | phosphorylation up-regulates → | TSC1 PThr417 | phosphorylation down-regulates ⊣ | TSC1 | 14551205 | SIGNOR-86696 |
| CDK1 | phosphorylation up-regulates → | TSC1 PSer584 | phosphorylation down-regulates ⊣ | TSC1 | 14551205 | SIGNOR-118588 |
| IKBKB | phosphorylation up-regulates → | TSC1 PSer511 | phosphorylation down-regulates ⊣ | TSC1 | 19188143 | SIGNOR-183692 |
| CyclinB/CDK1 | phosphorylation up-regulates → | TSC1 PThr1047 | phosphorylation down-regulates ⊣ | TSC1 | 14551205 | SIGNOR-216949 |
| CDK1 | phosphorylation up-regulates → | TSC1 PThr1047 | phosphorylation down-regulates ⊣ | TSC1 | 14551205 | SIGNOR-117339 |
| CDK1 | phosphorylation up-regulates → | TSC1 PThr417 | phosphorylation down-regulates ⊣ | TSC1 | 14551205 | SIGNOR-118584 |
| IKBKB | phosphorylation up-regulates → | TSC1 PSer487 | phosphorylation down-regulates ⊣ | TSC1 | 17693255 | SIGNOR-157296 |
| CDK1 | phosphorylation up-regulates → | TSC1 PThr1047 | phosphorylation down-regulates ⊣ | TSC1 | 14551205 | SIGNOR-118580 |
| CyclinB/CDK1 | phosphorylation up-regulates → | TSC1 PSer584 | phosphorylation down-regulates ⊣ | TSC1 | 14551205 | SIGNOR-216944 |
| CDK1 | phosphorylation up-regulates → | TSC1 PSer584 | phosphorylation down-regulates ⊣ | TSC1 | 14551205 | SIGNOR-118576 |
| IKBKB | phosphorylation up-regulates → | TSC1 PSer487 | phosphorylation down-regulates ⊣ | TSC1 | 19188143 | SIGNOR-183688 |
| CyclinB/CDK1 | phosphorylation up-regulates → | TSC1 PThr417 | phosphorylation down-regulates ⊣ | TSC1 | 14551205 | SIGNOR-216953 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AMPK | phosphorylation → up-regulates | TSC1 | SIGNOR-216487 |
| MAPK1 | phosphorylation down-regulates | TSC1 | SIGNOR-135692 |
| IKBKB | phosphorylation down-regulates | TSC1 | SIGNOR-157300 |
| PRKAA2 | phosphorylation → up-regulates | TSC1 | SIGNOR-119541 |
| ERK1/2 | phosphorylation down-regulates | TSC1 | SIGNOR-244761 |
| CDK1 | phosphorylation → unknown | TSC1 | SIGNOR-86696 |
| PLK1 | phosphorylation down-regulates quantity by destabilization | TSC1 | SIGNOR-280072 |
| AMPK | phosphorylation → up-regulates | TSC1 | SIGNOR-216441 |
| CDK1 | phosphorylation → unknown | TSC1 | SIGNOR-118588 |
| IKBKB | phosphorylation down-regulates | TSC1 | SIGNOR-183692 |
| CyclinB/CDK1 | phosphorylation down-regulates | TSC1 | SIGNOR-216949 |
| MAPK1 | phosphorylation down-regulates | TSC1 | SIGNOR-157162 |
| CDK1 | phosphorylation → unknown | TSC1 | SIGNOR-117339 |
| CDK1 | phosphorylation down-regulates | TSC1 | SIGNOR-118584 |
| IKBKB | phosphorylation down-regulates | TSC1 | SIGNOR-157296 |
| CDK1 | phosphorylation down-regulates | TSC1 | SIGNOR-118580 |
| CyclinB/CDK1 | phosphorylation down-regulates | TSC1 | SIGNOR-216944 |
| CDK1 | phosphorylation down-regulates | TSC1 | SIGNOR-118576 |
| IKBKB | phosphorylation down-regulates | TSC1 | SIGNOR-183688 |
| CyclinB/CDK1 | phosphorylation down-regulates | TSC1 | SIGNOR-216953 |
