| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | TSC1 | Thr417 | SLPQATVtPPRKEER | phosphorylation unknown | 14551205 | SIGNOR-86696 |
| CDK1 | TSC1 | Thr417 | SLPQATVtPPRKEER | phosphorylation down-regulates | 14551205 | SIGNOR-118584 |
| CyclinB/CDK1 | TSC1 | Thr417 | SLPQATVtPPRKEER | phosphorylation down-regulates | 14551205 | SIGNOR-216953 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | phosphorylation up-regulates → | TSC1 PThr417 | phosphorylation down-regulates ⊣ | TSC1 | 14551205 | SIGNOR-86696 |
| CDK1 | phosphorylation up-regulates → | TSC1 PThr417 | phosphorylation down-regulates ⊣ | TSC1 | 14551205 | SIGNOR-118584 |
| CyclinB/CDK1 | phosphorylation up-regulates → | TSC1 PThr417 | phosphorylation down-regulates ⊣ | TSC1 | 14551205 | SIGNOR-216953 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK1 | phosphorylation → unknown | TSC1 | SIGNOR-86696 |
| CDK1 | phosphorylation down-regulates | TSC1 | SIGNOR-118584 |
| CyclinB/CDK1 | phosphorylation down-regulates | TSC1 | SIGNOR-216953 |
