| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| IKBKB | TSC1 | Ser487 | AAISRELsEITTAEA | phosphorylation down-regulates | 17693255 | SIGNOR-157296 |
| IKBKB | TSC1 | Ser487 | AAISRELsEITTAEA | phosphorylation down-regulates | 19188143 | SIGNOR-183688 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| IKBKB | phosphorylation up-regulates → | TSC1 PSer487 | phosphorylation down-regulates ⊣ | TSC1 | 17693255 | SIGNOR-157296 |
| IKBKB | phosphorylation up-regulates → | TSC1 PSer487 | phosphorylation down-regulates ⊣ | TSC1 | 19188143 | SIGNOR-183688 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| IKBKB | phosphorylation![]() down-regulates | TSC1 | SIGNOR-157296 |
| IKBKB | phosphorylation![]() down-regulates | TSC1 | SIGNOR-183688 |