| Name | DYRK2 |
| ID | Q92630 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 222-535 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DYRK2 | TERT | – | phosphorylation down-regulates activity | 23362280 | SIGNOR-279611 | |
| DYRK2 | SIAH2 | Ser16 | PSANKPCsKQPPPQP | phosphorylation up-regulates | 22878263 | SIGNOR-198721 |
| DYRK2 | SIAH2 | Ser28 | PQPQHTPsPAAPPAA | phosphorylation up-regulates | 22878263 | SIGNOR-198725 |
| DYRK2 | SIAH2 | Ser68 | GGGAGPVsPQHHELT | phosphorylation up-regulates | 22878263 | SIGNOR-198729 |
| DYRK2 | SIAH2 | Thr119 | PTCRGALtPSIRNLA | phosphorylation up-regulates | 22878263 | SIGNOR-198733 |
| DYRK2 | SIAH2 | Thr26 | PPPQPQHtPSPAAPP | phosphorylation up-regulates | 22878263 | SIGNOR-198737 |
| DYRK2 | KATNA1 | Ser109 | VPVERRPsPGPRKRQ | phosphorylation down-regulates quantity by destabilization | 19287380 | SIGNOR-262847 |
| DYRK2 | KATNA1 | Ser42 | QMNKYLYsVKDTYLQ | phosphorylation down-regulates quantity by destabilization | 19287380 | SIGNOR-262848 |
| DYRK2 | KATNA1 | Thr133 | HGNRPSTtVRVHRSS | phosphorylation down-regulates quantity by destabilization | 19287380 | SIGNOR-262849 |
| DYRK2 | SNAI1 | Ser104 | GKGSQPPsPPSPAPS | phosphorylation down-regulates activity | 25603354 | SIGNOR-279328 |
| DYRK2 | TP53 | Ser46 | AMDDLMLsPDDIEQW | phosphorylation up-regulates | 17349958 | SIGNOR-153544 |
| DYRK2 | TP53 | Ser46 | AMDDLMLsPDDIEQW | phosphorylation up-regulates activity | 19965871 | SIGNOR-275578 |
| DYRK2 | JUN | Ser243 | PGETPPLsPIDMESQ | phosphorylation down-regulates | 22307329 | SIGNOR-195771 |
| DYRK2 | GLI2 | – | phosphorylation down-regulates quantity by destabilization | 18455992 | SIGNOR-279034 | |
| DYRK2 | CDC25A | Ser283 | PERSQEEsPPGSTKR | phosphorylation down-regulates quantity | 34363019 | SIGNOR-279367 |
| DYRK2 | CDC25A | Ser107 | NPMRRIHsLPQKLLG | phosphorylation down-regulates quantity by destabilization | 34363019 | SIGNOR-276738 |
| DYRK2 | CDC25A | Ser156 | KKPVRPVsRGCLHSH | phosphorylation down-regulates quantity by destabilization | 34363019 | SIGNOR-276740 |
| DYRK2 | CDC25A | Ser18 | RRLLFACsPPPASQP | phosphorylation down-regulates quantity by destabilization | 34363019 | SIGNOR-276736 |
| DYRK2 | CDC25A | Ser185 | SAPARMLsSNERDSS | phosphorylation down-regulates quantity by destabilization | 34363019 | SIGNOR-276739 |
| DYRK2 | CDC25A | Ser320 | HQSLSLAsSPKGTIE | phosphorylation down-regulates quantity by destabilization | 34363019 | SIGNOR-276734 |
| DYRK2 | CDC25A | Ser321 | QSLSLASsPKGTIEN | phosphorylation down-regulates quantity by destabilization | 34363019 | SIGNOR-276735 |
| DYRK2 | CDC25A | Ser88 | DSGFCLDsPGPLDSK | phosphorylation down-regulates quantity by destabilization | 34363019 | SIGNOR-276737 |
| DYRK2 | PSMC4 | Thr25 | LSVSRPQtGLSFLGP | phosphorylation down-regulates quantity by destabilization | 26655835 | SIGNOR-275845 |
| DYRK2 | NOTCH1 | – | phosphorylation down-regulates quantity by destabilization | 31605148 | SIGNOR-279035 | |
| DYRK2 | HSF1 | Ser320 | ASPGRPSsVDTLLSP | phosphorylation up-regulates activity | 33268814 | SIGNOR-278355 |
| DYRK2 | HSF1 | Ser326 | SSVDTLLsPTALIDS | phosphorylation up-regulates activity | 33268814 | SIGNOR-278356 |
| DYRK2 | DPYSL3 | Ser518 | KGGTPAGsARGSPTR | phosphorylation up-regulates activity | 16611631 | SIGNOR-145975 |
| DYRK2 | DPYSL3 | Thr509 | PVFDLTTtPKGGTPA | phosphorylation up-regulates activity | 16611631 | SIGNOR-145979 |
| DYRK2 | DPYSL3 | Thr514 | TTTPKGGtPAGSARG | phosphorylation up-regulates activity | 16611631 | SIGNOR-145987 |
| DYRK2 | TBK1 | Ser527 | QDIDSRLsPGGSLAD | phosphorylation down-regulates quantity by destabilization | 26407194 | SIGNOR-276939 |
| DYRK2 | CARHSP1 | Ser30 | TPRSRERsPSPLRGN | phosphorylation unknown | 15910284 | SIGNOR-137474 |
| DYRK2 | CARHSP1 | Ser32 | RSRERSPsPLRGNVV | phosphorylation unknown | 15910284 | SIGNOR-137478 |
| DYRK2 | CARHSP1 | Ser41 | LRGNVVPsPLPTRRT | phosphorylation unknown | 21177848 | SIGNOR-170781 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DYRK2 | phosphorylation up-regulates → | SIAH2 PSer16 | phosphorylation up-regulates → | SIAH2 | 22878263 | SIGNOR-198721 |
| DYRK2 | phosphorylation up-regulates → | SIAH2 PSer28 | phosphorylation up-regulates → | SIAH2 | 22878263 | SIGNOR-198725 |
| DYRK2 | phosphorylation up-regulates → | SIAH2 PSer68 | phosphorylation up-regulates → | SIAH2 | 22878263 | SIGNOR-198729 |
| DYRK2 | phosphorylation up-regulates → | SIAH2 PThr119 | phosphorylation up-regulates → | SIAH2 | 22878263 | SIGNOR-198733 |
| DYRK2 | phosphorylation up-regulates → | SIAH2 PThr26 | phosphorylation up-regulates → | SIAH2 | 22878263 | SIGNOR-198737 |
| DYRK2 | phosphorylation up-regulates → | KATNA1 PSer109 | phosphorylation down-regulates ⊣ | KATNA1 | 19287380 | SIGNOR-262847 |
| DYRK2 | phosphorylation up-regulates → | KATNA1 PSer42 | phosphorylation down-regulates ⊣ | KATNA1 | 19287380 | SIGNOR-262848 |
| DYRK2 | phosphorylation up-regulates → | KATNA1 PThr133 | phosphorylation down-regulates ⊣ | KATNA1 | 19287380 | SIGNOR-262849 |
| DYRK2 | phosphorylation up-regulates → | SNAI1 PSer104 | phosphorylation down-regulates ⊣ | SNAI1 | 25603354 | SIGNOR-279328 |
| DYRK2 | phosphorylation up-regulates → | TP53 PSer46 | phosphorylation up-regulates → | TP53 | 17349958 | SIGNOR-153544 |
| DYRK2 | phosphorylation up-regulates → | TP53 PSer46 | phosphorylation up-regulates → | TP53 | 19965871 | SIGNOR-275578 |
| DYRK2 | phosphorylation up-regulates → | JUN PSer243 | phosphorylation down-regulates ⊣ | JUN | 22307329 | SIGNOR-195771 |
| DYRK2 | phosphorylation up-regulates → | CDC25A PSer283 | phosphorylation down-regulates ⊣ | CDC25A | 34363019 | SIGNOR-279367 |
| DYRK2 | phosphorylation up-regulates → | CDC25A PSer107 | phosphorylation down-regulates ⊣ | CDC25A | 34363019 | SIGNOR-276738 |
| DYRK2 | phosphorylation up-regulates → | CDC25A PSer156 | phosphorylation down-regulates ⊣ | CDC25A | 34363019 | SIGNOR-276740 |
| DYRK2 | phosphorylation up-regulates → | CDC25A PSer18 | phosphorylation down-regulates ⊣ | CDC25A | 34363019 | SIGNOR-276736 |
| DYRK2 | phosphorylation up-regulates → | CDC25A PSer185 | phosphorylation down-regulates ⊣ | CDC25A | 34363019 | SIGNOR-276739 |
| DYRK2 | phosphorylation up-regulates → | CDC25A PSer320 | phosphorylation down-regulates ⊣ | CDC25A | 34363019 | SIGNOR-276734 |
| DYRK2 | phosphorylation up-regulates → | CDC25A PSer321 | phosphorylation down-regulates ⊣ | CDC25A | 34363019 | SIGNOR-276735 |
| DYRK2 | phosphorylation up-regulates → | CDC25A PSer88 | phosphorylation down-regulates ⊣ | CDC25A | 34363019 | SIGNOR-276737 |
| DYRK2 | phosphorylation up-regulates → | PSMC4 PThr25 | phosphorylation down-regulates ⊣ | PSMC4 | 26655835 | SIGNOR-275845 |
| DYRK2 | phosphorylation up-regulates → | HSF1 PSer320 | phosphorylation up-regulates → | HSF1 | 33268814 | SIGNOR-278355 |
| DYRK2 | phosphorylation up-regulates → | HSF1 PSer326 | phosphorylation up-regulates → | HSF1 | 33268814 | SIGNOR-278356 |
| DYRK2 | phosphorylation up-regulates → | DPYSL3 PSer518 | phosphorylation up-regulates → | DPYSL3 | 16611631 | SIGNOR-145975 |
| DYRK2 | phosphorylation up-regulates → | DPYSL3 PThr509 | phosphorylation up-regulates → | DPYSL3 | 16611631 | SIGNOR-145979 |
| DYRK2 | phosphorylation up-regulates → | DPYSL3 PThr514 | phosphorylation up-regulates → | DPYSL3 | 16611631 | SIGNOR-145987 |
| DYRK2 | phosphorylation up-regulates → | TBK1 PSer527 | phosphorylation down-regulates ⊣ | TBK1 | 26407194 | SIGNOR-276939 |
| DYRK2 | phosphorylation up-regulates → | CARHSP1 PSer30 | phosphorylation down-regulates ⊣ | CARHSP1 | 15910284 | SIGNOR-137474 |
| DYRK2 | phosphorylation up-regulates → | CARHSP1 PSer32 | phosphorylation down-regulates ⊣ | CARHSP1 | 15910284 | SIGNOR-137478 |
| DYRK2 | phosphorylation up-regulates → | CARHSP1 PSer41 | phosphorylation down-regulates ⊣ | CARHSP1 | 21177848 | SIGNOR-170781 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| DYRK2 | phosphorylation → down-regulates activity | TERT | SIGNOR-279611 |
| DYRK2 | phosphorylation → up-regulates | SIAH2 | SIGNOR-198721 |
| DYRK2 | phosphorylation → up-regulates | SIAH2 | SIGNOR-198725 |
| DYRK2 | phosphorylation → up-regulates | SIAH2 | SIGNOR-198729 |
| DYRK2 | phosphorylation → up-regulates | SIAH2 | SIGNOR-198733 |
| DYRK2 | phosphorylation → up-regulates | SIAH2 | SIGNOR-198737 |
| DYRK2 | phosphorylation down-regulates quantity by destabilization | KATNA1 | SIGNOR-262847 |
| DYRK2 | phosphorylation down-regulates quantity by destabilization | KATNA1 | SIGNOR-262848 |
| DYRK2 | phosphorylation down-regulates quantity by destabilization | KATNA1 | SIGNOR-262849 |
| DYRK2 | phosphorylation → down-regulates activity | SNAI1 | SIGNOR-279328 |
| DYRK2 | phosphorylation → up-regulates | TP53 | SIGNOR-153544 |
| DYRK2 | phosphorylation → up-regulates activity | TP53 | SIGNOR-275578 |
| DYRK2 | phosphorylation down-regulates | JUN | SIGNOR-195771 |
| DYRK2 | phosphorylation down-regulates quantity by destabilization | GLI2 | SIGNOR-279034 |
| DYRK2 | phosphorylation → down-regulates quantity | CDC25A | SIGNOR-279367 |
| DYRK2 | phosphorylation down-regulates quantity by destabilization | CDC25A | SIGNOR-276738 |
| DYRK2 | phosphorylation down-regulates quantity by destabilization | CDC25A | SIGNOR-276740 |
| DYRK2 | phosphorylation down-regulates quantity by destabilization | CDC25A | SIGNOR-276736 |
| DYRK2 | phosphorylation down-regulates quantity by destabilization | CDC25A | SIGNOR-276739 |
| DYRK2 | phosphorylation down-regulates quantity by destabilization | CDC25A | SIGNOR-276734 |
| DYRK2 | phosphorylation down-regulates quantity by destabilization | CDC25A | SIGNOR-276735 |
| DYRK2 | phosphorylation down-regulates quantity by destabilization | CDC25A | SIGNOR-276737 |
| DYRK2 | phosphorylation down-regulates quantity by destabilization | PSMC4 | SIGNOR-275845 |
| DYRK2 | phosphorylation down-regulates quantity by destabilization | NOTCH1 | SIGNOR-279035 |
| DYRK2 | phosphorylation → up-regulates activity | HSF1 | SIGNOR-278355 |
| DYRK2 | phosphorylation → up-regulates activity | HSF1 | SIGNOR-278356 |
| DYRK2 | phosphorylation → up-regulates activity | DPYSL3 | SIGNOR-145975 |
| DYRK2 | phosphorylation → up-regulates activity | DPYSL3 | SIGNOR-145979 |
| DYRK2 | phosphorylation → up-regulates activity | DPYSL3 | SIGNOR-145987 |
| DYRK2 | phosphorylation down-regulates quantity by destabilization | TBK1 | SIGNOR-276939 |
| DYRK2 | phosphorylation → unknown | CARHSP1 | SIGNOR-137474 |
| DYRK2 | phosphorylation → unknown | CARHSP1 | SIGNOR-137478 |
| DYRK2 | phosphorylation → unknown | CARHSP1 | SIGNOR-170781 |