Entity Details

Name DYRK2
ID Q92630
Role substrate
Enzymatic Domains
Protein kinase 222-535
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
CDC25ADYRK2–dephosphorylation
down-regulates activity		34363019SIGNOR-277098
ATMDYRK2Thr106NKRTVLTtQPNGLTTphosphorylation
up-regulates quantity by stabilization		19965871SIGNOR-275576
ATMDYRK2Ser442IELLGMPsQKLLDASphosphorylation
up-regulates quantity by stabilization		19965871SIGNOR-275577
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
ATMphosphorylation
up-regulates
→
DYRK2
PThr106		phosphorylation
up-regulates
→		DYRK219965871SIGNOR-275576
ATMphosphorylation
up-regulates
→
DYRK2
PSer442		phosphorylation
up-regulates
→		DYRK219965871SIGNOR-275577
Regulator Mechanism/Effect Target SIGNOR-ID
CDC25Adephosphorylation
→
down-regulates activity 		DYRK2SIGNOR-277098
ATMphosphorylation
→
up-regulates quantity by stabilization 		DYRK2SIGNOR-275576
ATMphosphorylation
→
up-regulates quantity by stabilization 		DYRK2SIGNOR-275577