| Name | RYR2 |
| ID | Q92736 |
| Role | substrate |
| Enzymatic Domains |
MIR 1 110-165 PROSITE-ProRule
MIR 2 172-217 PROSITE-ProRule
MIR 3 225-280 PROSITE-ProRule
MIR 4 286-343 PROSITE-ProRule
MIR 5 351-408 PROSITE-ProRule
B30.2/SPRY 1 599-809 PROSITE-ProRule
B30.2/SPRY 2 1025-1222 PROSITE-ProRule
B30.2/SPRY 3 1337-1562 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | RYR2 | Ser2808 | YNRTRRIsQTSQVSV | phosphorylation up-regulates activity | 14532276 | SIGNOR-250079 |
| SPEG | RYR2 | – | phosphorylation down-regulates activity | 32683896 | SIGNOR-279114 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | phosphorylation up-regulates → | RYR2 PSer2808 | phosphorylation up-regulates → | RYR2 | 14532276 | SIGNOR-250079 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKACA | phosphorylation → up-regulates activity | RYR2 | SIGNOR-250079 |
| SPEG | phosphorylation → down-regulates activity | RYR2 | SIGNOR-279114 |