| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| IKBKE | TANK | Ser178 | TATETQCsVPIQCTD | phosphorylation down-regulates activity | 10759890 | SIGNOR-262716 |
| IKBKE | TANK | Ser208 | DINRGAPsITSVTPR | phosphorylation down-regulates activity | 10759890 | SIGNOR-262717 |
| IKBKE | TANK | Ser257 | PERPGILsPATSEAV | phosphorylation down-regulates activity | 10759890 | SIGNOR-262719 |
| IKBKE | TANK | Ser49 | REQQEQLsLQQTIID | phosphorylation down-regulates activity | 10759890 | SIGNOR-262722 |
| IKBKE | TANK | Ser126 | RKETSARsLGSPLLH | phosphorylation down-regulates activity | 10759890 | SIGNOR-262715 |
| IKBKE | TANK | Ser228 | EEDTSFEsLSKFNVK | phosphorylation down-regulates activity | 10759890 | SIGNOR-262718 |
| IKBKE | TANK | Ser406 | CQAVFPPsITSRGDF | phosphorylation down-regulates activity | 10759890 | SIGNOR-262720 |
| IKBKE | TANK | Ser100 | QPQDKVIsGIAREKL | phosphorylation down-regulates activity | 10759890 | SIGNOR-262713 |
| IKBKE | TANK | Ser409 | VFPPSITsRGDFLRH | phosphorylation down-regulates activity | 10759890 | SIGNOR-262721 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| IKBKE | phosphorylation up-regulates → | TANK PSer178 | phosphorylation down-regulates ⊣ | TANK | 10759890 | SIGNOR-262716 |
| IKBKE | phosphorylation up-regulates → | TANK PSer208 | phosphorylation down-regulates ⊣ | TANK | 10759890 | SIGNOR-262717 |
| IKBKE | phosphorylation up-regulates → | TANK PSer257 | phosphorylation down-regulates ⊣ | TANK | 10759890 | SIGNOR-262719 |
| IKBKE | phosphorylation up-regulates → | TANK PSer49 | phosphorylation down-regulates ⊣ | TANK | 10759890 | SIGNOR-262722 |
| IKBKE | phosphorylation up-regulates → | TANK PSer126 | phosphorylation down-regulates ⊣ | TANK | 10759890 | SIGNOR-262715 |
| IKBKE | phosphorylation up-regulates → | TANK PSer228 | phosphorylation down-regulates ⊣ | TANK | 10759890 | SIGNOR-262718 |
| IKBKE | phosphorylation up-regulates → | TANK PSer406 | phosphorylation down-regulates ⊣ | TANK | 10759890 | SIGNOR-262720 |
| IKBKE | phosphorylation up-regulates → | TANK PSer100 | phosphorylation down-regulates ⊣ | TANK | 10759890 | SIGNOR-262713 |
| IKBKE | phosphorylation up-regulates → | TANK PSer409 | phosphorylation down-regulates ⊣ | TANK | 10759890 | SIGNOR-262721 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| IKBKE | phosphorylation → down-regulates activity | TANK | SIGNOR-262716 |
| IKBKE | phosphorylation → down-regulates activity | TANK | SIGNOR-262717 |
| IKBKE | phosphorylation → down-regulates activity | TANK | SIGNOR-262719 |
| IKBKE | phosphorylation → down-regulates activity | TANK | SIGNOR-262722 |
| IKBKE | phosphorylation → down-regulates activity | TANK | SIGNOR-262715 |
| IKBKE | phosphorylation → down-regulates activity | TANK | SIGNOR-262718 |
| IKBKE | phosphorylation → down-regulates activity | TANK | SIGNOR-262720 |
| IKBKE | phosphorylation → down-regulates activity | TANK | SIGNOR-262713 |
| IKBKE | phosphorylation → down-regulates activity | TANK | SIGNOR-262721 |
