Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
SMG1	UPF1	Thr28	AELLGADtQGSEFEF	phosphorylation up-regulates	23356578	SIGNOR-200793
SMG1	UPF1	Ser1107 View in OncoXplorer	SQIDVALsQDSTYQG	phosphorylation up-regulates	23356578	SIGNOR-200789
SMG1	UPF1	Ser1089	GLSQPELsQDSYLGD	phosphorylation up-regulates	23356578	SIGNOR-200785
AKT3	UPF1	Thr151	FCNGRGNtSGSHIVN	phosphorylation up-regulates activity	35675814	SIGNOR-277596
ATR	UPF1	–		phosphorylation up-regulates activity	29192227	SIGNOR-278911
AKT2	UPF1	Thr151	FCNGRGNtSGSHIVN	phosphorylation up-regulates activity	35675814	SIGNOR-277595
AKT1	UPF1	Thr151	FCNGRGNtSGSHIVN	phosphorylation up-regulates activity	35675814	SIGNOR-277597

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
SMG1	phosphorylation up-regulates →	UPF1 PThr28	phosphorylation up-regulates →	UPF1	23356578	SIGNOR-200793
SMG1	phosphorylation up-regulates →	UPF1 PSer1107	phosphorylation up-regulates →	UPF1	23356578	SIGNOR-200789
SMG1	phosphorylation up-regulates →	UPF1 PSer1089	phosphorylation up-regulates →	UPF1	23356578	SIGNOR-200785
AKT3	phosphorylation up-regulates →	UPF1 PThr151	phosphorylation up-regulates →	UPF1	35675814	SIGNOR-277596
AKT2	phosphorylation up-regulates →	UPF1 PThr151	phosphorylation up-regulates →	UPF1	35675814	SIGNOR-277595
AKT1	phosphorylation up-regulates →	UPF1 PThr151	phosphorylation up-regulates →	UPF1	35675814	SIGNOR-277597

Regulator	Mechanism/Effect	Target	SIGNOR-ID
SMG1	phosphorylation → up-regulates	UPF1	SIGNOR-200793
SMG1	phosphorylation → up-regulates	UPF1	SIGNOR-200789
SMG1	phosphorylation → up-regulates	UPF1	SIGNOR-200785
AKT3	phosphorylation → up-regulates activity	UPF1	SIGNOR-277596
ATR	phosphorylation → up-regulates activity	UPF1	SIGNOR-278911
AKT2	phosphorylation → up-regulates activity	UPF1	SIGNOR-277595
AKT1	phosphorylation → up-regulates activity	UPF1	SIGNOR-277597