| Name | UPF1 |
| ID | Q92900 |
| Role | substrate |
| Enzymatic Domains |
UPF1-type SF1B helicase ATP-binding 481-709 PROSITE-ProRule
UPF1-type SF1B helicase C-terminal 710-922 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SMG1 | UPF1 | Ser1107 | SQIDVALsQDSTYQG | phosphorylation up-regulates | 23356578 | SIGNOR-200789 |
| AKT1 | UPF1 | Thr151 | FCNGRGNtSGSHIVN | phosphorylation up-regulates activity | 35675814 | SIGNOR-277597 |
| AKT2 | UPF1 | Thr151 | FCNGRGNtSGSHIVN | phosphorylation up-regulates activity | 35675814 | SIGNOR-277595 |
| ATR | UPF1 | – | phosphorylation up-regulates activity | 29192227 | SIGNOR-278911 | |
| SMG1 | UPF1 | Ser1089 | GLSQPELsQDSYLGD | phosphorylation up-regulates | 23356578 | SIGNOR-200785 |
| SMG1 | UPF1 | Thr28 | AELLGADtQGSEFEF | phosphorylation up-regulates | 23356578 | SIGNOR-200793 |
| AKT3 | UPF1 | Thr151 | FCNGRGNtSGSHIVN | phosphorylation up-regulates activity | 35675814 | SIGNOR-277596 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SMG1 | phosphorylation up-regulates → | UPF1 PSer1107 | phosphorylation up-regulates → | UPF1 | 23356578 | SIGNOR-200789 |
| AKT1 | phosphorylation up-regulates → | UPF1 PThr151 | phosphorylation up-regulates → | UPF1 | 35675814 | SIGNOR-277597 |
| AKT2 | phosphorylation up-regulates → | UPF1 PThr151 | phosphorylation up-regulates → | UPF1 | 35675814 | SIGNOR-277595 |
| SMG1 | phosphorylation up-regulates → | UPF1 PSer1089 | phosphorylation up-regulates → | UPF1 | 23356578 | SIGNOR-200785 |
| SMG1 | phosphorylation up-regulates → | UPF1 PThr28 | phosphorylation up-regulates → | UPF1 | 23356578 | SIGNOR-200793 |
| AKT3 | phosphorylation up-regulates → | UPF1 PThr151 | phosphorylation up-regulates → | UPF1 | 35675814 | SIGNOR-277596 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| SMG1 | phosphorylation → up-regulates | UPF1 | SIGNOR-200789 |
| AKT1 | phosphorylation → up-regulates activity | UPF1 | SIGNOR-277597 |
| AKT2 | phosphorylation → up-regulates activity | UPF1 | SIGNOR-277595 |
| ATR | phosphorylation → up-regulates activity | UPF1 | SIGNOR-278911 |
| SMG1 | phosphorylation → up-regulates | UPF1 | SIGNOR-200785 |
| SMG1 | phosphorylation → up-regulates | UPF1 | SIGNOR-200793 |
| AKT3 | phosphorylation → up-regulates activity | UPF1 | SIGNOR-277596 |