| Name | MAP4K1 |
| ID | Q92918 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 17-274 PROSITE-ProRule
CNH 495-800 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP4K1 | GRAP2 | – | phosphorylation down-regulates activity | 22105350 | SIGNOR-279421 | |
| MAP4K1 | LCP2 | Ser376 | PRKQLSESSDDDYDD | phosphorylation down-regulates activity | 17353368 | SIGNOR-274153 |
| MAP4K1 | LCP2 | Ser376 | SSFPQSAsLPPYFSQ | phosphorylation up-regulates | 17353368 | SIGNOR-153613 |
| MAP4K1 | PSMD2 | Ser361 | ENNRFGGsGSQVDSA | phosphorylation up-regulates activity | 31843888 | SIGNOR-273899 |
| MAP4K1 | MAP3K1 | – | phosphorylation up-regulates | 8824585 | SIGNOR-43996 | |
| MAP4K1 | MAP3K11 | Ser281 | WHKTTQMsAAGTYAW | phosphorylation up-regulates | 11053428 | SIGNOR-83415 |
| MAP4K1 | MAP4K1 | Thr165 | ISAQIGAtLARRLSF | phosphorylation up-regulates | 15743830 | SIGNOR-134490 |
| MAP4K1 | CARD11 | Ser556 | TKMQPPRsRSSIMSI | phosphorylation up-regulates activity | 19706536 | SIGNOR-276259 |
| MAP4K1 | CARD11 | Ser558 | MQPPRSRsSIMSITA | phosphorylation up-regulates activity | 19706536 | SIGNOR-276257 |
| MAP4K1 | CARD11 | Ser559 | QPPRSRSsIMSITAE | phosphorylation up-regulates activity | 19706536 | SIGNOR-276258 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP4K1 | phosphorylation up-regulates → | LCP2 PSer376 | phosphorylation down-regulates ⊣ | LCP2 | 17353368 | SIGNOR-274153 |
| MAP4K1 | phosphorylation up-regulates → | LCP2 PSer376 | phosphorylation up-regulates → | LCP2 | 17353368 | SIGNOR-153613 |
| MAP4K1 | phosphorylation up-regulates → | PSMD2 PSer361 | phosphorylation up-regulates → | PSMD2 | 31843888 | SIGNOR-273899 |
| MAP4K1 | phosphorylation up-regulates → | MAP3K11 PSer281 | phosphorylation up-regulates → | MAP3K11 | 11053428 | SIGNOR-83415 |
| MAP4K1 | phosphorylation up-regulates → | MAP4K1 PThr165 | phosphorylation up-regulates → | MAP4K1 | 15743830 | SIGNOR-134490 |
| MAP4K1 | phosphorylation up-regulates → | CARD11 PSer556 | phosphorylation up-regulates → | CARD11 | 19706536 | SIGNOR-276259 |
| MAP4K1 | phosphorylation up-regulates → | CARD11 PSer558 | phosphorylation up-regulates → | CARD11 | 19706536 | SIGNOR-276257 |
| MAP4K1 | phosphorylation up-regulates → | CARD11 PSer559 | phosphorylation up-regulates → | CARD11 | 19706536 | SIGNOR-276258 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAP4K1 | phosphorylation → down-regulates activity | GRAP2 | SIGNOR-279421 |
| MAP4K1 | phosphorylation → down-regulates activity | LCP2 | SIGNOR-274153 |
| MAP4K1 | phosphorylation → up-regulates | LCP2 | SIGNOR-153613 |
| MAP4K1 | phosphorylation → up-regulates activity | PSMD2 | SIGNOR-273899 |
| MAP4K1 | phosphorylation → up-regulates | MAP3K1 | SIGNOR-43996 |
| MAP4K1 | phosphorylation → up-regulates | MAP3K11 | SIGNOR-83415 |
| MAP4K1 | phosphorylation → up-regulates | MAP4K1 | SIGNOR-134490 |
| MAP4K1 | phosphorylation → up-regulates activity | CARD11 | SIGNOR-276259 |
| MAP4K1 | phosphorylation → up-regulates activity | CARD11 | SIGNOR-276257 |
| MAP4K1 | phosphorylation → up-regulates activity | CARD11 | SIGNOR-276258 |