Entity Details

Name MAP4K1
ID Q92918
Role substrate
Enzymatic Domains
Protein kinase 17-274
PROSITE-ProRule
CNH 495-800
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
ABL1MAP4K1Tyr232FLMTKSGyQPPRLKEphosphorylation
up-regulates activity		11278340SIGNOR-251429
MAP4K1MAP4K1Thr165ISAQIGAtLARRLSFphosphorylation
up-regulates		15743830SIGNOR-134490
SYKMAP4K1Tyr381SESSDDDyDDVDIPTphosphorylation
up-regulates activity		11514608SIGNOR-246567
LYNMAP4K1Tyr381SESSDDDyDDVDIPTphosphorylation
up-regulates activity		11514608SIGNOR-251403
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
ABL1phosphorylation
up-regulates
→
MAP4K1
PTyr232		phosphorylation
up-regulates
→		MAP4K111278340SIGNOR-251429
MAP4K1phosphorylation
up-regulates
→
MAP4K1
PThr165		phosphorylation
up-regulates
→		MAP4K115743830SIGNOR-134490
SYKphosphorylation
up-regulates
→
MAP4K1
PTyr381		phosphorylation
up-regulates
→		MAP4K111514608SIGNOR-246567
LYNphosphorylation
up-regulates
→
MAP4K1
PTyr381		phosphorylation
up-regulates
→		MAP4K111514608SIGNOR-251403
Regulator Mechanism/Effect Target SIGNOR-ID
ABL1phosphorylation
→
up-regulates activity 		MAP4K1SIGNOR-251429
MAP4K1phosphorylation
→
up-regulates 		MAP4K1SIGNOR-134490
SYKphosphorylation
→
up-regulates activity 		MAP4K1SIGNOR-246567
LYNphosphorylation
→
up-regulates activity 		MAP4K1SIGNOR-251403