| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TBK1 | IRF7 | Ser479 | SLDSSSLsLCLSSAN | phosphorylation up-regulates activity | 22787218 | SIGNOR-278216 |
| IRAK1 | IRF7 | – | phosphorylation up-regulates activity | 15767370 | SIGNOR-278235 | |
| CHUK | IRF7 | – | phosphorylation up-regulates | 16612387 | SIGNOR-146116 | |
| IKBKE | IRF7 | Ser471 | GTQREGVsSLDSSSL | phosphorylation up-regulates | 10893229 | SIGNOR-79139 |
| IKBKE | IRF7 | Ser472 | TQREGVSsLDSSSLS | phosphorylation up-regulates | 10893229 | SIGNOR-79143 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TBK1 | phosphorylation up-regulates → | IRF7 PSer479 | phosphorylation up-regulates → | IRF7 | 22787218 | SIGNOR-278216 |
| IKBKE | phosphorylation up-regulates → | IRF7 PSer471 | phosphorylation up-regulates → | IRF7 | 10893229 | SIGNOR-79139 |
| IKBKE | phosphorylation up-regulates → | IRF7 PSer472 | phosphorylation up-regulates → | IRF7 | 10893229 | SIGNOR-79143 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| TBK1 | phosphorylation → up-regulates activity | IRF7 | SIGNOR-278216 |
| IRAK1 | phosphorylation → up-regulates activity | IRF7 | SIGNOR-278235 |
| CHUK | phosphorylation → up-regulates | IRF7 | SIGNOR-146116 |
| IKBKE | phosphorylation → up-regulates | IRF7 | SIGNOR-79139 |
| IKBKE | phosphorylation → up-regulates | IRF7 | SIGNOR-79143 |
