| Name | KAT5 |
| ID | Q92993 |
| Role | substrate |
| Enzymatic Domains |
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MYST-type HAT 227-504 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | KAT5 | Ser90 | LPGSRPGsPEREVPA | phosphorylation up-regulates | 16103124 | SIGNOR-139653 |
| PRKCE | KAT5 | – | phosphorylation up-regulates activity | 17851107 | SIGNOR-279309 | |
| MAPK14 | KAT5 | Thr158 | VEVVSPAtPVPSETA | phosphorylation up-regulates activity | 25544752 | SIGNOR-278958 |
| ABL1 | KAT5 | Tyr294 | HPPGNEIyRKGTISF | phosphorylation down-regulates activity | 24044023 | SIGNOR-276598 |
| CyclinB/CDK1 | KAT5 | Ser86 | TKNGLPGsRPGSPER | phosphorylation up-regulates activity | 12468530 | SIGNOR-250641 |
| GSK3B | KAT5 | Ser86 | TKNGLPGsRPGSPER | phosphorylation up-regulates | 21658600 | SIGNOR-174049 |
| CDK1 | KAT5 | Ser86 | TKNGLPGsRPGSPER | phosphorylation up-regulates | 16103124 | SIGNOR-139649 |
| CyclinB/CDK1 | KAT5 | Ser90 | LPGSRPGsPEREVPA | phosphorylation up-regulates activity | 12468530 | SIGNOR-250642 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | phosphorylation up-regulates → | KAT5 PSer90 | phosphorylation up-regulates → | KAT5 | 16103124 | SIGNOR-139653 |
| MAPK14 | phosphorylation up-regulates → | KAT5 PThr158 | phosphorylation up-regulates → | KAT5 | 25544752 | SIGNOR-278958 |
| ABL1 | phosphorylation up-regulates → | KAT5 PTyr294 | phosphorylation down-regulates ⊣ | KAT5 | 24044023 | SIGNOR-276598 |
| CyclinB/CDK1 | phosphorylation up-regulates → | KAT5 PSer86 | phosphorylation up-regulates → | KAT5 | 12468530 | SIGNOR-250641 |
| GSK3B | phosphorylation up-regulates → | KAT5 PSer86 | phosphorylation up-regulates → | KAT5 | 21658600 | SIGNOR-174049 |
| CDK1 | phosphorylation up-regulates → | KAT5 PSer86 | phosphorylation up-regulates → | KAT5 | 16103124 | SIGNOR-139649 |
| CyclinB/CDK1 | phosphorylation up-regulates → | KAT5 PSer90 | phosphorylation up-regulates → | KAT5 | 12468530 | SIGNOR-250642 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK1 | phosphorylation → up-regulates | KAT5 | SIGNOR-139653 |
| PRKCE | phosphorylation → up-regulates activity | KAT5 | SIGNOR-279309 |
| MAPK14 | phosphorylation → up-regulates activity | KAT5 | SIGNOR-278958 |
| ABL1 | phosphorylation → down-regulates activity | KAT5 | SIGNOR-276598 |
| CyclinB/CDK1 | phosphorylation → up-regulates activity | KAT5 | SIGNOR-250641 |
| GSK3B | phosphorylation → up-regulates | KAT5 | SIGNOR-174049 |
| CDK1 | phosphorylation → up-regulates | KAT5 | SIGNOR-139649 |
| CyclinB/CDK1 | phosphorylation → up-regulates activity | KAT5 | SIGNOR-250642 |