Entity Details

Name USP7
ID Q93009
Role substrate
Enzymatic Domains
MATH 68-195
PROSITE-ProRule
USP 214-521
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PPM1GUSP7Ser18
View in OncoXplorer
KAGEQQLsEPEDMEMdephosphorylation
down-regulates quantity by destabilization		22361354SIGNOR-276531
CSNK2A1USP7Ser18
View in OncoXplorer
KAGEQQLsEPEDMEMphosphorylation
up-regulates quantity by stabilization		22361354SIGNOR-276530
PPM1GUSP7–dephosphorylation
down-regulates activity		22361354SIGNOR-277159
BCR-ABLUSP7Tyr243NQLRKAVyMMPTEGDphosphorylation
up-regulates activity		24317448SIGNOR-276532
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PPM1Gdephosphorylation
down-regulates
⊣
USP7
PSer18		dephosphorylation
up-regulates
→		USP722361354SIGNOR-276531
CSNK2A1phosphorylation
up-regulates
→
USP7
PSer18		phosphorylation
up-regulates
→		USP722361354SIGNOR-276530
BCR-ABLphosphorylation
up-regulates
→
USP7
PTyr243		phosphorylation
up-regulates
→		USP724317448SIGNOR-276532
Regulator Mechanism/Effect Target SIGNOR-ID
PPM1Gdephosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		USP7SIGNOR-276531
CSNK2A1phosphorylation
→
up-regulates quantity by stabilization 		USP7SIGNOR-276530
PPM1Gdephosphorylation
→
down-regulates activity 		USP7SIGNOR-277159
BCR-ABLphosphorylation
→
up-regulates activity 		USP7SIGNOR-276532