| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1G | USP7 | Ser18 | KAGEQQLsEPEDMEM | dephosphorylation down-regulates quantity by destabilization | 22361354 | SIGNOR-276531 |
| CSNK2A1 | USP7 | Ser18 | KAGEQQLsEPEDMEM | phosphorylation up-regulates quantity by stabilization | 22361354 | SIGNOR-276530 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1G | dephosphorylation down-regulates ⊣ | USP7 PSer18 | dephosphorylation up-regulates → | USP7 | 22361354 | SIGNOR-276531 |
| CSNK2A1 | phosphorylation up-regulates → | USP7 PSer18 | phosphorylation up-regulates → | USP7 | 22361354 | SIGNOR-276530 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPM1G | dephosphorylation![]() down-regulates quantity by destabilization | USP7 | SIGNOR-276531 |
| CSNK2A1 | phosphorylation → up-regulates quantity by stabilization | USP7 | SIGNOR-276530 |