Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
PRKCI	FBXW7	Ser18	KRRRTGGsLRGNPSS	phosphorylation down-regulates activity	28850619	SIGNOR-277250
PRKCA	FBXW7	Ser18	KRRRTGGsLRGNPSS	phosphorylation down-regulates activity	28850619	SIGNOR-277249
SGK1	FBXW7	Ser227	QQRRRITsVQPPTGL	phosphorylation up-regulates	21147854	SIGNOR-170404
PLK2	FBXW7	Ser176	KRKLDHGsEVRSFSL	phosphorylation down-regulates	22399798	SIGNOR-196448
AKT1	FBXW7	Ser227	QQRRRITsVQPPTGL	phosphorylation up-regulates activity	21620836	SIGNOR-276328
ATM	FBXW7	Ser26	LRGNPSSsQVDEEQM	phosphorylation up-regulates activity	26774286	SIGNOR-259942

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
PRKCI	phosphorylation up-regulates →	FBXW7 PSer18	phosphorylation down-regulates ⊣	FBXW7	28850619	SIGNOR-277250
PRKCA	phosphorylation up-regulates →	FBXW7 PSer18	phosphorylation down-regulates ⊣	FBXW7	28850619	SIGNOR-277249
SGK1	phosphorylation up-regulates →	FBXW7 PSer227	phosphorylation up-regulates →	FBXW7	21147854	SIGNOR-170404
PLK2	phosphorylation up-regulates →	FBXW7 PSer176	phosphorylation down-regulates ⊣	FBXW7	22399798	SIGNOR-196448
AKT1	phosphorylation up-regulates →	FBXW7 PSer227	phosphorylation up-regulates →	FBXW7	21620836	SIGNOR-276328
ATM	phosphorylation up-regulates →	FBXW7 PSer26	phosphorylation up-regulates →	FBXW7	26774286	SIGNOR-259942

Regulator	Mechanism/Effect	Target	SIGNOR-ID
PRKCI	phosphorylation → down-regulates activity	FBXW7	SIGNOR-277250
PRKCA	phosphorylation → down-regulates activity	FBXW7	SIGNOR-277249
SGK1	phosphorylation → up-regulates	FBXW7	SIGNOR-170404
PLK2	phosphorylation down-regulates	FBXW7	SIGNOR-196448
AKT1	phosphorylation → up-regulates activity	FBXW7	SIGNOR-276328
ATM	phosphorylation → up-regulates activity	FBXW7	SIGNOR-259942