| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | FBXW7 | Ser18 | KRRRTGGsLRGNPSS | phosphorylation down-regulates activity | 28850619 | SIGNOR-277249 |
| PRKCI | FBXW7 | Ser18 | KRRRTGGsLRGNPSS | phosphorylation down-regulates activity | 28850619 | SIGNOR-277250 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | phosphorylation up-regulates → | FBXW7 PSer18 | phosphorylation down-regulates ⊣ | FBXW7 | 28850619 | SIGNOR-277249 |
| PRKCI | phosphorylation up-regulates → | FBXW7 PSer18 | phosphorylation down-regulates ⊣ | FBXW7 | 28850619 | SIGNOR-277250 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCA | phosphorylation → down-regulates activity | FBXW7 | SIGNOR-277249 |
| PRKCI | phosphorylation → down-regulates activity | FBXW7 | SIGNOR-277250 |