| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK4 | FBXW5 | Ser151 | SQFNKDDsLLLASGV | phosphorylation down-regulates activity | 21725316 | SIGNOR-275476 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK4 | phosphorylation up-regulates → | FBXW5 PSer151 | phosphorylation down-regulates ⊣ | FBXW5 | 21725316 | SIGNOR-275476 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PLK4 | phosphorylation → down-regulates activity | FBXW5 | SIGNOR-275476 |
