| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT2 | AKT1S1 | Thr246 | LPRPRLNtSDFQKLK | phosphorylation down-regulates activity | 12524439 | SIGNOR-248046 |
| AKT2 | AKT1S1 | – | phosphorylation down-regulates | 17277771 | SIGNOR-152936 | |
| MTOR | AKT1S1 | Ser212 | EENGPPSsPDLDRIA | phosphorylation down-regulates activity | 18372248 | SIGNOR-178124 |
| DYRK3 | AKT1S1 | Thr246 | LPRPRLNtSDFQKLK | phosphorylation down-regulates activity | 23415227 | SIGNOR-279167 |
| AKT | AKT1S1 | Thr246 | LPRPRLNtSDFQKLK | phosphorylation down-regulates activity | 12524439 | SIGNOR-236929 |
| MTOR | AKT1S1 | Ser183 | PTQQYAKsLPVSVPV | phosphorylation down-regulates activity | 18372248 | SIGNOR-178120 |
| AKT2 | AKT1S1 | – | phosphorylation down-regulates | 17386266 | SIGNOR-153931 | |
| MTOR | AKT1S1 | Ser221 | DLDRIAAsMRALVLR | phosphorylation down-regulates activity | 18372248 | SIGNOR-178128 |
| AKT1 | AKT1S1 | Thr246 | LPRPRLNtSDFQKLK | phosphorylation down-regulates activity | 12524439 | SIGNOR-252544 |
| DYRK3 | AKT1S1 | – | phosphorylation down-regulates | 23415227 | SIGNOR-201002 | |
| MTOR | AKT1S1 | Ser183 | PTQQYAKsLPVSVPV | phosphorylation down-regulates activity | 17517883 | SIGNOR-154956 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT2 | phosphorylation up-regulates → | AKT1S1 PThr246 | phosphorylation down-regulates ⊣ | AKT1S1 | 12524439 | SIGNOR-248046 |
| MTOR | phosphorylation up-regulates → | AKT1S1 PSer212 | phosphorylation down-regulates ⊣ | AKT1S1 | 18372248 | SIGNOR-178124 |
| DYRK3 | phosphorylation up-regulates → | AKT1S1 PThr246 | phosphorylation down-regulates ⊣ | AKT1S1 | 23415227 | SIGNOR-279167 |
| AKT | phosphorylation up-regulates → | AKT1S1 PThr246 | phosphorylation down-regulates ⊣ | AKT1S1 | 12524439 | SIGNOR-236929 |
| MTOR | phosphorylation up-regulates → | AKT1S1 PSer183 | phosphorylation down-regulates ⊣ | AKT1S1 | 18372248 | SIGNOR-178120 |
| MTOR | phosphorylation up-regulates → | AKT1S1 PSer221 | phosphorylation down-regulates ⊣ | AKT1S1 | 18372248 | SIGNOR-178128 |
| AKT1 | phosphorylation up-regulates → | AKT1S1 PThr246 | phosphorylation down-regulates ⊣ | AKT1S1 | 12524439 | SIGNOR-252544 |
| MTOR | phosphorylation up-regulates → | AKT1S1 PSer183 | phosphorylation down-regulates ⊣ | AKT1S1 | 17517883 | SIGNOR-154956 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT2 | phosphorylation → down-regulates activity | AKT1S1 | SIGNOR-248046 |
| AKT2 | phosphorylation down-regulates | AKT1S1 | SIGNOR-152936 |
| MTOR | phosphorylation → down-regulates activity | AKT1S1 | SIGNOR-178124 |
| DYRK3 | phosphorylation → down-regulates activity | AKT1S1 | SIGNOR-279167 |
| AKT | phosphorylation → down-regulates activity | AKT1S1 | SIGNOR-236929 |
| MTOR | phosphorylation → down-regulates activity | AKT1S1 | SIGNOR-178120 |
| AKT2 | phosphorylation down-regulates | AKT1S1 | SIGNOR-153931 |
| MTOR | phosphorylation → down-regulates activity | AKT1S1 | SIGNOR-178128 |
| AKT1 | phosphorylation → down-regulates activity | AKT1S1 | SIGNOR-252544 |
| DYRK3 | phosphorylation down-regulates | AKT1S1 | SIGNOR-201002 |
| MTOR | phosphorylation → down-regulates activity | AKT1S1 | SIGNOR-154956 |
