Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
SGK3	FOXO3	Ser253	APRRRAVsMDNSNKY	phosphorylation down-regulates activity	11154281	SIGNOR-249135
SGK3	TSC2	–		phosphorylation up-regulates activity	34911733	SIGNOR-279284
SGK3	GSK3A	Ser21	SGRARTSsFAEPGGG	phosphorylation down-regulates activity	16543730	SIGNOR-249165
SGK3	GSK3B	Ser9	SGRPRTTsFAESCKP	phosphorylation down-regulates activity	12054501	SIGNOR-249166
SGK3	GSK3B	Ser9	SGRPRTTsFAESCKP	phosphorylation down-regulates activity	16543730	SIGNOR-249167
SGK3	FLII	Ser436	RLRRRKDsAQDDQAK	phosphorylation up-regulates	19293151	SIGNOR-184688
SGK3	FLII	Thr818	LHRPRHAtVSRSLEG	phosphorylation up-regulates	19293151	SIGNOR-184692
SGK3	SCN5A	Ser484	KRRKRMSsGTEECGE	phosphorylation up-regulates activity	33410863	SIGNOR-275767
SGK3	SCN5A	Ser664	GARQRALsAVSVLTS	phosphorylation up-regulates activity	33410863	SIGNOR-275768
SGK3	ARL6IP4	–		phosphorylation down-regulates activity	23201781	SIGNOR-280124
SGK3	PTOV1	Ser36	VRAVRSRsWPASPRG	phosphorylation down-regulates quantity by destabilization	34654719	SIGNOR-279283
SGK3	NDRG1	–		phosphorylation down-regulates activity	25458846	SIGNOR-279282
SGK3	NEDD4L	–		phosphorylation down-regulates activity	15496163	SIGNOR-280125
SGK3	PIKFYVE	Ser318	LSLDRSGsPMVPSYE	phosphorylation up-regulates activity	22470488	SIGNOR-279113
SGK3	FOXO	Ser253	APRRRAVsMDNSNKY	phosphorylation down-regulates activity	11154281	SIGNOR-252992

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
SGK3	phosphorylation up-regulates →	FOXO3 PSer253	phosphorylation down-regulates ⊣	FOXO3	11154281	SIGNOR-249135
SGK3	phosphorylation up-regulates →	GSK3A PSer21	phosphorylation down-regulates ⊣	GSK3A	16543730	SIGNOR-249165
SGK3	phosphorylation up-regulates →	GSK3B PSer9	phosphorylation down-regulates ⊣	GSK3B	12054501	SIGNOR-249166
SGK3	phosphorylation up-regulates →	GSK3B PSer9	phosphorylation down-regulates ⊣	GSK3B	16543730	SIGNOR-249167
SGK3	phosphorylation up-regulates →	FLII PSer436	phosphorylation up-regulates →	FLII	19293151	SIGNOR-184688
SGK3	phosphorylation up-regulates →	FLII PThr818	phosphorylation up-regulates →	FLII	19293151	SIGNOR-184692
SGK3	phosphorylation up-regulates →	SCN5A PSer484	phosphorylation up-regulates →	SCN5A	33410863	SIGNOR-275767
SGK3	phosphorylation up-regulates →	SCN5A PSer664	phosphorylation up-regulates →	SCN5A	33410863	SIGNOR-275768
SGK3	phosphorylation up-regulates →	PTOV1 PSer36	phosphorylation down-regulates ⊣	PTOV1	34654719	SIGNOR-279283
SGK3	phosphorylation up-regulates →	PIKFYVE PSer318	phosphorylation up-regulates →	PIKFYVE	22470488	SIGNOR-279113
SGK3	phosphorylation up-regulates →	FOXO PSer253	phosphorylation down-regulates ⊣	FOXO	11154281	SIGNOR-252992

Regulator	Mechanism/Effect	Target	SIGNOR-ID
SGK3	phosphorylation → down-regulates activity	FOXO3	SIGNOR-249135
SGK3	phosphorylation → up-regulates activity	TSC2	SIGNOR-279284
SGK3	phosphorylation → down-regulates activity	GSK3A	SIGNOR-249165
SGK3	phosphorylation → down-regulates activity	GSK3B	SIGNOR-249166
SGK3	phosphorylation → down-regulates activity	GSK3B	SIGNOR-249167
SGK3	phosphorylation → up-regulates	FLII	SIGNOR-184688
SGK3	phosphorylation → up-regulates	FLII	SIGNOR-184692
SGK3	phosphorylation → up-regulates activity	SCN5A	SIGNOR-275767
SGK3	phosphorylation → up-regulates activity	SCN5A	SIGNOR-275768
SGK3	phosphorylation → down-regulates activity	ARL6IP4	SIGNOR-280124
SGK3	phosphorylation down-regulates quantity by destabilization	PTOV1	SIGNOR-279283
SGK3	phosphorylation → down-regulates activity	NDRG1	SIGNOR-279282
SGK3	phosphorylation → down-regulates activity	NEDD4L	SIGNOR-280125
SGK3	phosphorylation → up-regulates activity	PIKFYVE	SIGNOR-279113
SGK3	phosphorylation → down-regulates activity	FOXO	SIGNOR-252992