| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AURKB | CHMP4C | Ser210 | MSSTARRsRAASSQR | phosphorylation up-regulates | 22724069 | SIGNOR-197967 |
| AURKB | CHMP4C | Ser214 | ARRSRAAsSQRAEEE | phosphorylation up-regulates | 22724069 | SIGNOR-197971 |
| AURKB | CHMP4C | Ser215 | RRSRAASsQRAEEED | phosphorylation up-regulates | 22422861 | SIGNOR-196728 |
| ULK3 | CHMP4C | – | phosphorylation down-regulates activity | 26011858 | SIGNOR-279771 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AURKB | phosphorylation up-regulates → | CHMP4C PSer210 | phosphorylation up-regulates → | CHMP4C | 22724069 | SIGNOR-197967 |
| AURKB | phosphorylation up-regulates → | CHMP4C PSer214 | phosphorylation up-regulates → | CHMP4C | 22724069 | SIGNOR-197971 |
| AURKB | phosphorylation up-regulates → | CHMP4C PSer215 | phosphorylation up-regulates → | CHMP4C | 22422861 | SIGNOR-196728 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AURKB | phosphorylation → up-regulates | CHMP4C | SIGNOR-197967 |
| AURKB | phosphorylation → up-regulates | CHMP4C | SIGNOR-197971 |
| AURKB | phosphorylation → up-regulates | CHMP4C | SIGNOR-196728 |
| ULK3 | phosphorylation → down-regulates activity | CHMP4C | SIGNOR-279771 |
