| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TBK1 | OPTN | Ser177 | SSGSSEDsFVEIRMA | phosphorylation up-regulates activity | 26365381 | SIGNOR-278169 |
| TBK1 | OPTN | Ser513 | FEDGGRQsLMEMQSR | phosphorylation up-regulates activity | 26365381 | SIGNOR-278171 |
| PLK1 | OPTN | Ser177 | SSGSSEDsFVEIRMA | phosphorylation up-regulates | 22365832 | SIGNOR-196367 |
| TBK1 | OPTN | Ser473 | AQMEVYCsDFHAERA | phosphorylation up-regulates activity | 26365381 | SIGNOR-278170 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TBK1 | phosphorylation up-regulates → | OPTN PSer177 | phosphorylation up-regulates → | OPTN | 26365381 | SIGNOR-278169 |
| TBK1 | phosphorylation up-regulates → | OPTN PSer513 | phosphorylation up-regulates → | OPTN | 26365381 | SIGNOR-278171 |
| PLK1 | phosphorylation up-regulates → | OPTN PSer177 | phosphorylation up-regulates → | OPTN | 22365832 | SIGNOR-196367 |
| TBK1 | phosphorylation up-regulates → | OPTN PSer473 | phosphorylation up-regulates → | OPTN | 26365381 | SIGNOR-278170 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| TBK1 | phosphorylation → up-regulates activity | OPTN | SIGNOR-278169 |
| TBK1 | phosphorylation → up-regulates activity | OPTN | SIGNOR-278171 |
| PLK1 | phosphorylation → up-regulates | OPTN | SIGNOR-196367 |
| TBK1 | phosphorylation → up-regulates activity | OPTN | SIGNOR-278170 |
