| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK2 | AURKB | Ser331 | HPWVRANsRRVLPPS | phosphorylation up-regulates activity | 24798733 | SIGNOR-278906 |
| CHEK1 | AURKB | Ser331 | HPWVRANsRRVLPPS | phosphorylation up-regulates | 17276342 | SIGNOR-152926 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK2 | phosphorylation up-regulates → | AURKB PSer331 | phosphorylation up-regulates → | AURKB | 24798733 | SIGNOR-278906 |
| CHEK1 | phosphorylation up-regulates → | AURKB PSer331 | phosphorylation up-regulates → | AURKB | 17276342 | SIGNOR-152926 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CHEK2 | phosphorylation → up-regulates activity | AURKB | SIGNOR-278906 |
| CHEK1 | phosphorylation → up-regulates | AURKB | SIGNOR-152926 |
