| Name | MASTL |
| ID | Q96GX5 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 35-835 PROSITE-ProRule
AGC-kinase C-terminal 836-879 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | MASTL | Thr207 | PRQDYSRtPGQVLSL | phosphorylation up-regulates activity | 22354989 | SIGNOR-249653 |
| CyclinA2/CDK2 | MASTL | Thr194 | NMMDILTtPSMAKPR | phosphorylation up-regulates activity | 24391510 | SIGNOR-276614 |
| CDK1 | MASTL | Thr194 | NMMDILTtPSMAKPR | phosphorylation up-regulates activity | 22354989 | SIGNOR-243414 |
| CyclinB/CDK1 | MASTL | Thr194 | NMMDILTtPSMAKPR | phosphorylation up-regulates activity | 22354989 | SIGNOR-243403 |
| CTDP1 | MASTL | Ser453 | NFELVDSsPCKKIIQ | dephosphorylation down-regulates activity | 26653855 | SIGNOR-276971 |
| CTDP1 | MASTL | Ser90 | DALALSKsPFIVHLY | dephosphorylation down-regulates activity | 26653855 | SIGNOR-276972 |
| MASTL | MASTL | Ser875 | TAQHLTVsGFSL | phosphorylation up-regulates activity | 22354989 | SIGNOR-243409 |
| PP2CA_R1A_R2A | MASTL | Thr194 | NMMDILTtPSMAKPR | dephosphorylation down-regulates activity | 24391510 | SIGNOR-276615 |
| CyclinB/CDK1 | MASTL | Thr207 | PRQDYSRtPGQVLSL | phosphorylation up-regulates activity | 22354989 | SIGNOR-249652 |
| AKT1 | MASTL | Thr299 | QSRKRLAtSSASSQS | phosphorylation up-regulates activity | 32123010 | SIGNOR-277515 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | phosphorylation up-regulates → | MASTL PThr207 | phosphorylation up-regulates → | MASTL | 22354989 | SIGNOR-249653 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | MASTL PThr194 | phosphorylation up-regulates → | MASTL | 24391510 | SIGNOR-276614 |
| CDK1 | phosphorylation up-regulates → | MASTL PThr194 | phosphorylation up-regulates → | MASTL | 22354989 | SIGNOR-243414 |
| CyclinB/CDK1 | phosphorylation up-regulates → | MASTL PThr194 | phosphorylation up-regulates → | MASTL | 22354989 | SIGNOR-243403 |
| CTDP1 | dephosphorylation down-regulates ⊣ | MASTL PSer453 | dephosphorylation up-regulates → | MASTL | 26653855 | SIGNOR-276971 |
| CTDP1 | dephosphorylation down-regulates ⊣ | MASTL PSer90 | dephosphorylation up-regulates → | MASTL | 26653855 | SIGNOR-276972 |
| MASTL | phosphorylation up-regulates → | MASTL PSer875 | phosphorylation up-regulates → | MASTL | 22354989 | SIGNOR-243409 |
| PP2CA_R1A_R2A | dephosphorylation down-regulates ⊣ | MASTL PThr194 | dephosphorylation up-regulates → | MASTL | 24391510 | SIGNOR-276615 |
| CyclinB/CDK1 | phosphorylation up-regulates → | MASTL PThr207 | phosphorylation up-regulates → | MASTL | 22354989 | SIGNOR-249652 |
| AKT1 | phosphorylation up-regulates → | MASTL PThr299 | phosphorylation up-regulates → | MASTL | 32123010 | SIGNOR-277515 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK1 | phosphorylation → up-regulates activity | MASTL | SIGNOR-249653 |
| CyclinA2/CDK2 | phosphorylation → up-regulates activity | MASTL | SIGNOR-276614 |
| CDK1 | phosphorylation → up-regulates activity | MASTL | SIGNOR-243414 |
| CyclinB/CDK1 | phosphorylation → up-regulates activity | MASTL | SIGNOR-243403 |
| CTDP1 | dephosphorylation → down-regulates activity | MASTL | SIGNOR-276971 |
| CTDP1 | dephosphorylation → down-regulates activity | MASTL | SIGNOR-276972 |
| MASTL | phosphorylation → up-regulates activity | MASTL | SIGNOR-243409 |
| PP2CA_R1A_R2A | dephosphorylation → down-regulates activity | MASTL | SIGNOR-276615 |
| CyclinB/CDK1 | phosphorylation → up-regulates activity | MASTL | SIGNOR-249652 |
| AKT1 | phosphorylation → up-regulates activity | MASTL | SIGNOR-277515 |