| Name | ITCH |
| ID | Q96J02 |
| Role | substrate |
| Enzymatic Domains |
C2 1-115 PROSITE-ProRule
WW 1 326-359 PROSITE-ProRule
WW 2 358-391 PROSITE-ProRule
WW 3 438-471 PROSITE-ProRule
WW 4 478-511 PROSITE-ProRule
HECT 569-903 PROSITE-ProRule |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSK | ITCH | – | phosphorylation down-regulates activity | 16888620 | SIGNOR-245327 | |
| MAPK8 | ITCH | Ser240 | RRVSGNNsPSLSNGG | phosphorylation up-regulates activity | 16446428 | SIGNOR-245323 |
| AKT1 | ITCH | Ser257 | PSRPPRPsRPPPPTP | phosphorylation up-regulates quantity | 30517763 | SIGNOR-272922 |
| MAPK8 | ITCH | Thr263 | PSRPPPPtPRRPASV | phosphorylation up-regulates activity | 16446428 | SIGNOR-249579 |
| MAPK8 | ITCH | – | phosphorylation up-regulates activity | 15358865 | SIGNOR-245315 | |
| MAPK8 | ITCH | – | phosphorylation up-regulates | 16469705 | SIGNOR-144456 | |
| ATM | ITCH | Ser162 | TCSENGVsLCLPRLE | phosphorylation up-regulates activity | 23435430 | SIGNOR-276488 |
| MAPK8 | ITCH | – | phosphorylation up-regulates activity | 16469705 | SIGNOR-245310 | |
| FYN | ITCH | Tyr420 | QFNQRFIyGNQDLFA | phosphorylation down-regulates activity | 16387660 | SIGNOR-245332 |
| MAPK8 | ITCH | Ser273 | RPASVNGsPSATSES | phosphorylation up-regulates activity | 16446428 | SIGNOR-249580 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK8 | phosphorylation up-regulates → | ITCH PSer240 | phosphorylation up-regulates → | ITCH | 16446428 | SIGNOR-245323 |
| AKT1 | phosphorylation up-regulates → | ITCH PSer257 | phosphorylation up-regulates → | ITCH | 30517763 | SIGNOR-272922 |
| MAPK8 | phosphorylation up-regulates → | ITCH PThr263 | phosphorylation up-regulates → | ITCH | 16446428 | SIGNOR-249579 |
| ATM | phosphorylation up-regulates → | ITCH PSer162 | phosphorylation up-regulates → | ITCH | 23435430 | SIGNOR-276488 |
| FYN | phosphorylation up-regulates → | ITCH PTyr420 | phosphorylation down-regulates ⊣ | ITCH | 16387660 | SIGNOR-245332 |
| MAPK8 | phosphorylation up-regulates → | ITCH PSer273 | phosphorylation up-regulates → | ITCH | 16446428 | SIGNOR-249580 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CSK | phosphorylation → down-regulates activity | ITCH | SIGNOR-245327 |
| MAPK8 | phosphorylation → up-regulates activity | ITCH | SIGNOR-245323 |
| AKT1 | phosphorylation → up-regulates quantity | ITCH | SIGNOR-272922 |
| MAPK8 | phosphorylation → up-regulates activity | ITCH | SIGNOR-249579 |
| MAPK8 | phosphorylation → up-regulates activity | ITCH | SIGNOR-245315 |
| MAPK8 | phosphorylation → up-regulates | ITCH | SIGNOR-144456 |
| ATM | phosphorylation → up-regulates activity | ITCH | SIGNOR-276488 |
| MAPK8 | phosphorylation → up-regulates activity | ITCH | SIGNOR-245310 |
| FYN | phosphorylation → down-regulates activity | ITCH | SIGNOR-245332 |
| MAPK8 | phosphorylation → up-regulates activity | ITCH | SIGNOR-249580 |