| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| FYN | ITCH | Tyr420 | QFNQRFIyGNQDLFA | phosphorylation down-regulates activity | 16387660 | SIGNOR-245332 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| FYN | phosphorylation up-regulates → | ITCH PTyr420 | phosphorylation down-regulates ⊣ | ITCH | 16387660 | SIGNOR-245332 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| FYN | phosphorylation → down-regulates activity | ITCH | SIGNOR-245332 |
