Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
WNK4	OXSR1	–		phosphorylation up-regulates activity	22342722	SIGNOR-278389
WNK4	SLC12A3	Thr50	SHLTHSStFCMRTFG	phosphorylation up-regulates activity	22342722	SIGNOR-264631
WNK4	WNK4	Ser335	KRASFAKsVIGTPEF	phosphorylation down-regulates activity	25542968	SIGNOR-276871
WNK4	STK39	Ser371	VRRVPGSsGHLHKTE	phosphorylation up-regulates activity	16990453	SIGNOR-264641
WNK4	STK39	Thr231	TRNKVRKtFVGTPCW	phosphorylation up-regulates activity	16990453	SIGNOR-264640

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
WNK4	phosphorylation up-regulates →	SLC12A3 PThr50	phosphorylation up-regulates →	SLC12A3	22342722	SIGNOR-264631
WNK4	phosphorylation up-regulates →	WNK4 PSer335	phosphorylation down-regulates ⊣	WNK4	25542968	SIGNOR-276871
WNK4	phosphorylation up-regulates →	STK39 PSer371	phosphorylation up-regulates →	STK39	16990453	SIGNOR-264641
WNK4	phosphorylation up-regulates →	STK39 PThr231	phosphorylation up-regulates →	STK39	16990453	SIGNOR-264640

Regulator	Mechanism/Effect	Target	SIGNOR-ID
WNK4	phosphorylation → up-regulates activity	OXSR1	SIGNOR-278389
WNK4	phosphorylation → up-regulates activity	SLC12A3	SIGNOR-264631
WNK4	phosphorylation → down-regulates activity	WNK4	SIGNOR-276871
WNK4	phosphorylation → up-regulates activity	STK39	SIGNOR-264641
WNK4	phosphorylation → up-regulates activity	STK39	SIGNOR-264640