| Name | WNK4 |
| ID | Q96J92 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 174-432 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SGK1 | WNK4 | Ser1201 | FPTSRRNsLQRSEPP | phosphorylation up-regulates activity | 23054253 | SIGNOR-276421 |
| SRC | WNK4 | Tyr1113 | PSPVWMNySYSSLCL | phosphorylation down-regulates activity | 25805816 | SIGNOR-276897 |
| WNK4 | WNK4 | Ser335 | KRASFAKsVIGTPEF | phosphorylation down-regulates activity | 25542968 | SIGNOR-276871 |
| SGK1 | WNK4 | Ser1217 | PGIMRRNsLSGSSTG | phosphorylation down-regulates activity | 27517916 | SIGNOR-278453 |
| SGK1 | WNK4 | Ser1190 | SSRQRRLsKGSFPTS | phosphorylation down-regulates activity | 27517916 | SIGNOR-278454 |
| SRC | WNK4 | Tyr1115 | PVWMNYSySSLCLSS | phosphorylation down-regulates activity | 25805816 | SIGNOR-276895 |
| SRC | WNK4 | Tyr1164 | KKEIEDLySRLGKQP | phosphorylation down-regulates activity | 25805816 | SIGNOR-276896 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SGK1 | phosphorylation up-regulates → | WNK4 PSer1201 | phosphorylation up-regulates → | WNK4 | 23054253 | SIGNOR-276421 |
| SRC | phosphorylation up-regulates → | WNK4 PTyr1113 | phosphorylation down-regulates ⊣ | WNK4 | 25805816 | SIGNOR-276897 |
| WNK4 | phosphorylation up-regulates → | WNK4 PSer335 | phosphorylation down-regulates ⊣ | WNK4 | 25542968 | SIGNOR-276871 |
| SGK1 | phosphorylation up-regulates → | WNK4 PSer1217 | phosphorylation down-regulates ⊣ | WNK4 | 27517916 | SIGNOR-278453 |
| SGK1 | phosphorylation up-regulates → | WNK4 PSer1190 | phosphorylation down-regulates ⊣ | WNK4 | 27517916 | SIGNOR-278454 |
| SRC | phosphorylation up-regulates → | WNK4 PTyr1115 | phosphorylation down-regulates ⊣ | WNK4 | 25805816 | SIGNOR-276895 |
| SRC | phosphorylation up-regulates → | WNK4 PTyr1164 | phosphorylation down-regulates ⊣ | WNK4 | 25805816 | SIGNOR-276896 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| SGK1 | phosphorylation → up-regulates activity | WNK4 | SIGNOR-276421 |
| SRC | phosphorylation → down-regulates activity | WNK4 | SIGNOR-276897 |
| WNK4 | phosphorylation → down-regulates activity | WNK4 | SIGNOR-276871 |
| SGK1 | phosphorylation → down-regulates activity | WNK4 | SIGNOR-278453 |
| SGK1 | phosphorylation → down-regulates activity | WNK4 | SIGNOR-278454 |
| SRC | phosphorylation → down-regulates activity | WNK4 | SIGNOR-276895 |
| SRC | phosphorylation → down-regulates activity | WNK4 | SIGNOR-276896 |