| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SGK1 | WNK4 | Ser1217 | PGIMRRNsLSGSSTG | phosphorylation down-regulates activity | 27517916 | SIGNOR-278453 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SGK1 | phosphorylation up-regulates → | WNK4 PSer1217 | phosphorylation down-regulates ⊣ | WNK4 | 27517916 | SIGNOR-278453 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| SGK1 | phosphorylation → down-regulates activity | WNK4 | SIGNOR-278453 |