| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| WNK4 | WNK4 | Ser335 | KRASFAKsVIGTPEF | phosphorylation down-regulates activity | 25542968 | SIGNOR-276871 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| WNK4 | phosphorylation up-regulates → | WNK4 PSer335 | phosphorylation down-regulates ⊣ | WNK4 | 25542968 | SIGNOR-276871 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| WNK4 | phosphorylation → down-regulates activity | WNK4 | SIGNOR-276871 |