Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
PBK	ULK1	Ser469	IRRSGSTsPLGFARA	phosphorylation down-regulates activity	31378785	SIGNOR-277474
PBK	ULK1	Ser495	GVLARKMsLGGGRPY	phosphorylation down-regulates activity	31378785	SIGNOR-277473
PBK	ULK1	Ser533	AEMRGGRsPRPGSSA	phosphorylation down-regulates activity	31378785	SIGNOR-277472
PBK	JUN	Ser63	KNSDLLTsPDVGLLK	phosphorylation up-regulates activity	26745678	SIGNOR-278155
PBK	JUN	Ser73	VGLLKLAsPELERLI	phosphorylation up-regulates activity	26745678	SIGNOR-278156
PBK	MAPK1	–		phosphorylation up-regulates activity	17631144	SIGNOR-278417
PBK	MAPK8	–		phosphorylation up-regulates activity	17545598	SIGNOR-280061
PBK	PTEN	Ser380	EPDHYRYsDTTDSDP	phosphorylation down-regulates activity	24012691	SIGNOR-271472
PBK	H3C1	Ser11	TKQTARKsTGGKAPR	phosphorylation unknown	16982762	SIGNOR-149716
PBK	GPSM2	Thr457	LKGKKYKtNSSTKVL	phosphorylation up-regulates	20589935	SIGNOR-166461
PBK	PRDX1	Ser32 View in OncoXplorer	QFKDISLsDYKGKYV	phosphorylation up-regulates	20647304	SIGNOR-166901
PBK	HDAC1	–		phosphorylation up-regulates activity	29896413	SIGNOR-279086
PBK	HDAC2	–		phosphorylation up-regulates activity	29896413	SIGNOR-279087
PBK	TP53RK	Ser250	RLRGRKRsMVG	phosphorylation up-regulates activity	28412249	SIGNOR-278236
PBK	Histone H3	–		phosphorylation unknown	16982762	SIGNOR-265364

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
PBK	phosphorylation up-regulates →	ULK1 PSer469	phosphorylation down-regulates ⊣	ULK1	31378785	SIGNOR-277474
PBK	phosphorylation up-regulates →	ULK1 PSer495	phosphorylation down-regulates ⊣	ULK1	31378785	SIGNOR-277473
PBK	phosphorylation up-regulates →	ULK1 PSer533	phosphorylation down-regulates ⊣	ULK1	31378785	SIGNOR-277472
PBK	phosphorylation up-regulates →	JUN PSer63	phosphorylation up-regulates →	JUN	26745678	SIGNOR-278155
PBK	phosphorylation up-regulates →	JUN PSer73	phosphorylation up-regulates →	JUN	26745678	SIGNOR-278156
PBK	phosphorylation up-regulates →	PTEN PSer380	phosphorylation down-regulates ⊣	PTEN	24012691	SIGNOR-271472
PBK	phosphorylation up-regulates →	H3C1 PSer11	phosphorylation down-regulates ⊣	H3C1	16982762	SIGNOR-149716
PBK	phosphorylation up-regulates →	GPSM2 PThr457	phosphorylation up-regulates →	GPSM2	20589935	SIGNOR-166461
PBK	phosphorylation up-regulates →	PRDX1 PSer32	phosphorylation up-regulates →	PRDX1	20647304	SIGNOR-166901
PBK	phosphorylation up-regulates →	TP53RK PSer250	phosphorylation up-regulates →	TP53RK	28412249	SIGNOR-278236

Regulator	Mechanism/Effect	Target	SIGNOR-ID
PBK	phosphorylation → down-regulates activity	ULK1	SIGNOR-277474
PBK	phosphorylation → down-regulates activity	ULK1	SIGNOR-277473
PBK	phosphorylation → down-regulates activity	ULK1	SIGNOR-277472
PBK	phosphorylation → up-regulates activity	JUN	SIGNOR-278155
PBK	phosphorylation → up-regulates activity	JUN	SIGNOR-278156
PBK	phosphorylation → up-regulates activity	MAPK1	SIGNOR-278417
PBK	phosphorylation → up-regulates activity	MAPK8	SIGNOR-280061
PBK	phosphorylation → down-regulates activity	PTEN	SIGNOR-271472
PBK	phosphorylation → unknown	H3C1	SIGNOR-149716
PBK	phosphorylation → up-regulates	GPSM2	SIGNOR-166461
PBK	phosphorylation → up-regulates	PRDX1	SIGNOR-166901
PBK	phosphorylation → up-regulates activity	HDAC1	SIGNOR-279086
PBK	phosphorylation → up-regulates activity	HDAC2	SIGNOR-279087
PBK	phosphorylation → up-regulates activity	TP53RK	SIGNOR-278236
PBK	phosphorylation → unknown	Histone H3	SIGNOR-265364