Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
MARK4	MAPT	Ser396	DDKKAKTsTRSSAKT	phosphorylation down-regulates activity	21204788	SIGNOR-273935
MARK4	MAPT	Ser420	KHPTPGSsDPLIQPS	phosphorylation down-regulates activity	21204788	SIGNOR-273936
MARK4	MAPT	Ser353	RHLSNVSsTGSIDMV	phosphorylation down-regulates activity	21204788	SIGNOR-273934
MARK4	MAPT	Ser262	NVKSKIGsTENLKHQ	phosphorylation down-regulates activity	21204788	SIGNOR-273933
MARK4	MAPT	Thr231	KKVAVVRtPPKSPSS	phosphorylation down-regulates activity	21204788	SIGNOR-273932
MARK4	TNK1	Ser502	RMKGISRsLESVLSL	phosphorylation down-regulates activity	34504101	SIGNOR-273865
MARK4	ODF2	–		phosphorylation up-regulates activity	23400999	SIGNOR-278961

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
MARK4	phosphorylation up-regulates →	MAPT PSer396	phosphorylation down-regulates ⊣	MAPT	21204788	SIGNOR-273935
MARK4	phosphorylation up-regulates →	MAPT PSer420	phosphorylation down-regulates ⊣	MAPT	21204788	SIGNOR-273936
MARK4	phosphorylation up-regulates →	MAPT PSer353	phosphorylation down-regulates ⊣	MAPT	21204788	SIGNOR-273934
MARK4	phosphorylation up-regulates →	MAPT PSer262	phosphorylation down-regulates ⊣	MAPT	21204788	SIGNOR-273933
MARK4	phosphorylation up-regulates →	MAPT PThr231	phosphorylation down-regulates ⊣	MAPT	21204788	SIGNOR-273932
MARK4	phosphorylation up-regulates →	TNK1 PSer502	phosphorylation down-regulates ⊣	TNK1	34504101	SIGNOR-273865

Regulator	Mechanism/Effect	Target	SIGNOR-ID
MARK4	phosphorylation → down-regulates activity	MAPT	SIGNOR-273935
MARK4	phosphorylation → down-regulates activity	MAPT	SIGNOR-273936
MARK4	phosphorylation → down-regulates activity	MAPT	SIGNOR-273934
MARK4	phosphorylation → down-regulates activity	MAPT	SIGNOR-273933
MARK4	phosphorylation → down-regulates activity	MAPT	SIGNOR-273932
MARK4	phosphorylation → down-regulates activity	TNK1	SIGNOR-273865
MARK4	phosphorylation → up-regulates activity	ODF2	SIGNOR-278961