| Name | SIGLEC10 |
| ID | Q96LC7 |
| Role | substrate |
| Enzymatic Domains |
Ig-like V-type 18-121
Ig-like C2-type 1 146-231
Ig-like C2-type 2 251-339
Ig-like C2-type 3 344-441 |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ITK | SIGLEC10 | Tyr597 | RHSTILDyINVVPTA | phosphorylation up-regulates | 11733002 | SIGNOR-112471 |
| LCK | SIGLEC10 | Tyr691 | PKGTQADyAEVKFQ | phosphorylation unknown | 11733002 | SIGNOR-112499 |
| JAK3 | SIGLEC10 | Tyr667 | ESQEELHyATLNFPG | phosphorylation up-regulates | 11733002 | SIGNOR-112483 |
| ITK | SIGLEC10 | Tyr667 | ESQEELHyATLNFPG | phosphorylation up-regulates | 11733002 | SIGNOR-112475 |
| LCK | SIGLEC10 | Tyr597 | RHSTILDyINVVPTA | phosphorylation up-regulates | 11733002 | SIGNOR-112491 |
| JAK3 | SIGLEC10 | Tyr691 | PKGTQADyAEVKFQ | phosphorylation unknown | 11733002 | SIGNOR-112487 |
| LCK | SIGLEC10 | Tyr667 | ESQEELHyATLNFPG | phosphorylation up-regulates | 11733002 | SIGNOR-112495 |
| JAK3 | SIGLEC10 | Tyr597 | RHSTILDyINVVPTA | phosphorylation up-regulates | 11733002 | SIGNOR-112479 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ITK | phosphorylation up-regulates → | SIGLEC10 PTyr597 | phosphorylation up-regulates → | SIGLEC10 | 11733002 | SIGNOR-112471 |
| LCK | phosphorylation up-regulates → | SIGLEC10 PTyr691 | phosphorylation down-regulates ⊣ | SIGLEC10 | 11733002 | SIGNOR-112499 |
| JAK3 | phosphorylation up-regulates → | SIGLEC10 PTyr667 | phosphorylation up-regulates → | SIGLEC10 | 11733002 | SIGNOR-112483 |
| ITK | phosphorylation up-regulates → | SIGLEC10 PTyr667 | phosphorylation up-regulates → | SIGLEC10 | 11733002 | SIGNOR-112475 |
| LCK | phosphorylation up-regulates → | SIGLEC10 PTyr597 | phosphorylation up-regulates → | SIGLEC10 | 11733002 | SIGNOR-112491 |
| JAK3 | phosphorylation up-regulates → | SIGLEC10 PTyr691 | phosphorylation down-regulates ⊣ | SIGLEC10 | 11733002 | SIGNOR-112487 |
| LCK | phosphorylation up-regulates → | SIGLEC10 PTyr667 | phosphorylation up-regulates → | SIGLEC10 | 11733002 | SIGNOR-112495 |
| JAK3 | phosphorylation up-regulates → | SIGLEC10 PTyr597 | phosphorylation up-regulates → | SIGLEC10 | 11733002 | SIGNOR-112479 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ITK | phosphorylation → up-regulates | SIGLEC10 | SIGNOR-112471 |
| LCK | phosphorylation → unknown | SIGLEC10 | SIGNOR-112499 |
| JAK3 | phosphorylation → up-regulates | SIGLEC10 | SIGNOR-112483 |
| ITK | phosphorylation → up-regulates | SIGLEC10 | SIGNOR-112475 |
| LCK | phosphorylation → up-regulates | SIGLEC10 | SIGNOR-112491 |
| JAK3 | phosphorylation → unknown | SIGLEC10 | SIGNOR-112487 |
| LCK | phosphorylation → up-regulates | SIGLEC10 | SIGNOR-112495 |
| JAK3 | phosphorylation → up-regulates | SIGLEC10 | SIGNOR-112479 |