Entity Details

Name	JAK3_Tyr667
ID	Q96LC7
Role	residue
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Data Summary

PTM Format

SIGNOR Summary

Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
JAK3	SIGLEC10	Tyr667	ESQEELHyATLNFPG	phosphorylation up-regulates	11733002	SIGNOR-112483
ITK	SIGLEC10	Tyr667	ESQEELHyATLNFPG	phosphorylation up-regulates	11733002	SIGNOR-112475
LCK	SIGLEC10	Tyr667	ESQEELHyATLNFPG	phosphorylation up-regulates	11733002	SIGNOR-112495

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
JAK3	phosphorylation up-regulates →	SIGLEC10 PTyr667	phosphorylation up-regulates →	SIGLEC10	11733002	SIGNOR-112483
ITK	phosphorylation up-regulates →	SIGLEC10 PTyr667	phosphorylation up-regulates →	SIGLEC10	11733002	SIGNOR-112475
LCK	phosphorylation up-regulates →	SIGLEC10 PTyr667	phosphorylation up-regulates →	SIGLEC10	11733002	SIGNOR-112495

Regulator	Mechanism/Effect	Target	SIGNOR-ID
JAK3	phosphorylation → up-regulates	SIGLEC10	SIGNOR-112483
ITK	phosphorylation → up-regulates	SIGLEC10	SIGNOR-112475
LCK	phosphorylation → up-regulates	SIGLEC10	SIGNOR-112495