| Name | NLRP3 |
| ID | Q96P20 |
| Role | substrate |
| Enzymatic Domains |
Pyrin 1-93 PROSITE-ProRule
FISNA 140-210 Notice: Undefined index: source in /home/prisca/signor/PhosphoSIGNOR/results/getDomains.php on line 17 Notice: Undefined index: source in /home/prisca/signor/PhosphoSIGNOR/results/getDomains.php on line 20 Notice: Undefined index: source in /home/prisca/signor/PhosphoSIGNOR/results/getDomains.php on line 23 Notice: Undefined index: source in /home/prisca/signor/PhosphoSIGNOR/results/getDomains.php on line 26
NACHT 220-536 PROSITE-ProRule |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN22 | NLRP3 | – | dephosphorylation up-regulates activity | 28786745 | SIGNOR-277056 | |
| PAK1 | NLRP3 | – | phosphorylation up-regulates activity | 33432150 | SIGNOR-278967 | |
| PKA | NLRP3 | Ser295 | HKIVRKPsRILFLMD | phosphorylation down-regulates activity | 27548431 | SIGNOR-277274 |
| LYN | NLRP3 | Tyr918 | NQNLTHLyLRGNTLG | phosphorylation down-regulates | 34699250 | SIGNOR-278485 |
| MAPK8 | NLRP3 | Ser198 | GKTKTCEsPVSPIKM | phosphorylation up-regulates activity | 28943315 | SIGNOR-277324 |
| PAK1 | NLRP3 | Thr659 | KIEINLStRMDHMVS | phosphorylation up-regulates activity | 33432150 | SIGNOR-277547 |
| MAPK8 | NLRP3 | – | phosphorylation up-regulates activity | 32787872 | SIGNOR-280034 | |
| MINK1 | NLRP3 | – | phosphorylation up-regulates activity | 34480147 | SIGNOR-280042 | |
| PRKD1 | NLRP3 | – | phosphorylation up-regulates activity | 28716882 | SIGNOR-279428 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKA | phosphorylation up-regulates → | NLRP3 PSer295 | phosphorylation down-regulates ⊣ | NLRP3 | 27548431 | SIGNOR-277274 |
| LYN | phosphorylation up-regulates → | NLRP3 PTyr918 | phosphorylation down-regulates ⊣ | NLRP3 | 34699250 | SIGNOR-278485 |
| MAPK8 | phosphorylation up-regulates → | NLRP3 PSer198 | phosphorylation up-regulates → | NLRP3 | 28943315 | SIGNOR-277324 |
| PAK1 | phosphorylation up-regulates → | NLRP3 PThr659 | phosphorylation up-regulates → | NLRP3 | 33432150 | SIGNOR-277547 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN22 | dephosphorylation → up-regulates activity | NLRP3 | SIGNOR-277056 |
| PAK1 | phosphorylation → up-regulates activity | NLRP3 | SIGNOR-278967 |
| PKA | phosphorylation → down-regulates activity | NLRP3 | SIGNOR-277274 |
| LYN | phosphorylation down-regulates | NLRP3 | SIGNOR-278485 |
| MAPK8 | phosphorylation → up-regulates activity | NLRP3 | SIGNOR-277324 |
| PAK1 | phosphorylation → up-regulates activity | NLRP3 | SIGNOR-277547 |
| MAPK8 | phosphorylation → up-regulates activity | NLRP3 | SIGNOR-280034 |
| MINK1 | phosphorylation → up-regulates activity | NLRP3 | SIGNOR-280042 |
| PRKD1 | phosphorylation → up-regulates activity | NLRP3 | SIGNOR-279428 |