| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKA | NLRP3 | Ser295 | HKIVRKPsRILFLMD | phosphorylation down-regulates activity | 27548431 | SIGNOR-277274 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKA | phosphorylation up-regulates → | NLRP3 PSer295 | phosphorylation down-regulates ⊣ | NLRP3 | 27548431 | SIGNOR-277274 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PKA | phosphorylation → down-regulates activity | NLRP3 | SIGNOR-277274 |