| Name | NOX5 |
| ID | Q96PH1 |
| Role | substrate |
| Enzymatic Domains |
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EF-hand 2 57-92 PROSITE-ProRule
EF-hand 3; atypical; contains an insert of 28 residues 93-156 PROSITE-ProRule
EF-hand 4 165-200 PROSITE-ProRule
Ferric oxidoreductase 293-440
FAD-binding FR-type 441-577 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CAMK2A | NOX5 | Ser521 | WTNRLYEsFKASDPL | phosphorylation up-regulates activity | 21642394 | SIGNOR-276329 |
| CAMK2A | NOX5 | Thr540 | KRLSRSVtMRKSQRS | phosphorylation unknown | 21642394 | SIGNOR-276330 |
| CAMK2A | NOX5 | Ser544 | RSVTMRKsQRSSKGS | phosphorylation unknown | 21642394 | SIGNOR-276331 |
| PRKCA | NOX5 | Ser544 | RSVTMRKsQRSSKGS | phosphorylation up-regulates | 24505490 | SIGNOR-204550 |
| PRKCA | NOX5 | Thr540 | KRLSRSVtMRKSQRS | phosphorylation up-regulates | 24505490 | SIGNOR-204554 |
| ABL1 | NOX5 | – | phosphorylation up-regulates activity | 32792487 | SIGNOR-280170 | |
| CAMK2A | NOX5 | Ser547 | TMRKSQRsSKGSEIL | phosphorylation unknown | 21642394 | SIGNOR-276332 |
| MAPK1 | NOX5 | Ser544 | RSVTMRKsQRSSKGS | phosphorylation up-regulates | 21297032 | SIGNOR-171847 |
| CAMK2A | NOX5 | Ser548 | MRKSQRSsKGSEILL | phosphorylation unknown | 21642394 | SIGNOR-276333 |
| PRKCA | NOX5 | Ser536 | GRGSKRLsRSVTMRK | phosphorylation up-regulates | 24505490 | SIGNOR-204546 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CAMK2A | phosphorylation up-regulates → | NOX5 PSer521 | phosphorylation up-regulates → | NOX5 | 21642394 | SIGNOR-276329 |
| CAMK2A | phosphorylation up-regulates → | NOX5 PThr540 | phosphorylation down-regulates ⊣ | NOX5 | 21642394 | SIGNOR-276330 |
| CAMK2A | phosphorylation up-regulates → | NOX5 PSer544 | phosphorylation down-regulates ⊣ | NOX5 | 21642394 | SIGNOR-276331 |
| PRKCA | phosphorylation up-regulates → | NOX5 PSer544 | phosphorylation up-regulates → | NOX5 | 24505490 | SIGNOR-204550 |
| PRKCA | phosphorylation up-regulates → | NOX5 PThr540 | phosphorylation up-regulates → | NOX5 | 24505490 | SIGNOR-204554 |
| CAMK2A | phosphorylation up-regulates → | NOX5 PSer547 | phosphorylation down-regulates ⊣ | NOX5 | 21642394 | SIGNOR-276332 |
| MAPK1 | phosphorylation up-regulates → | NOX5 PSer544 | phosphorylation up-regulates → | NOX5 | 21297032 | SIGNOR-171847 |
| CAMK2A | phosphorylation up-regulates → | NOX5 PSer548 | phosphorylation down-regulates ⊣ | NOX5 | 21642394 | SIGNOR-276333 |
| PRKCA | phosphorylation up-regulates → | NOX5 PSer536 | phosphorylation up-regulates → | NOX5 | 24505490 | SIGNOR-204546 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CAMK2A | phosphorylation → up-regulates activity | NOX5 | SIGNOR-276329 |
| CAMK2A | phosphorylation → unknown | NOX5 | SIGNOR-276330 |
| CAMK2A | phosphorylation → unknown | NOX5 | SIGNOR-276331 |
| PRKCA | phosphorylation → up-regulates | NOX5 | SIGNOR-204550 |
| PRKCA | phosphorylation → up-regulates | NOX5 | SIGNOR-204554 |
| ABL1 | phosphorylation → up-regulates activity | NOX5 | SIGNOR-280170 |
| CAMK2A | phosphorylation → unknown | NOX5 | SIGNOR-276332 |
| MAPK1 | phosphorylation → up-regulates | NOX5 | SIGNOR-171847 |
| CAMK2A | phosphorylation → unknown | NOX5 | SIGNOR-276333 |
| PRKCA | phosphorylation → up-regulates | NOX5 | SIGNOR-204546 |