| Name | NEDD4L |
| ID | Q96PU5 |
| Role | substrate |
| Enzymatic Domains |
C2 4-126 PROSITE-ProRule
WW 1 193-226 PROSITE-ProRule
WW 2 385-418 PROSITE-ProRule
WW 3 497-530 PROSITE-ProRule
WW 4 548-581 PROSITE-ProRule
HECT 640-974 PROSITE-ProRule |
View in  |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SGK3 | NEDD4L | – | phosphorylation down-regulates activity | 15496163 | SIGNOR-280125 | |
| SGK1 | NEDD4L | – | phosphorylation down-regulates activity | 15586017 | SIGNOR-251949 | |
| PRKACA | NEDD4L | Ser448 | IRRPRSLsSPTVTLS | phosphorylation down-regulates | 15328345 | SIGNOR-128429 |
| AMPK | NEDD4L | Ser795 | VDLKPNGsEIMVTNE | phosphorylation up-regulates activity | 21501591 | SIGNOR-276326 |
| SGK1 | NEDD4L | Ser448 | IRRPRSLsSPTVTLS | phosphorylation down-regulates | 15677482 | SIGNOR-133438 |
| SGK1 | NEDD4L | Thr383 | PSVAYVHtTPGLPSG | phosphorylation down-regulates activity | 12911626 | SIGNOR-263076 |
| AMPK | NEDD4L | Ser795 | VDLKPNGsEIMVTNE | phosphorylation up-regulates activity | 21501591 | SIGNOR-276324 |
| AMPK | NEDD4L | Ser795 | VDLKPNGsEIMVTNE | phosphorylation up-regulates activity | 21501591 | SIGNOR-277858 |
| SGK1 | NEDD4L | Ser342 | SSRLRSCsVTDAVAE | phosphorylation up-regulates | 11742982 | SIGNOR-113052 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | phosphorylation up-regulates → | NEDD4L PSer448 | phosphorylation down-regulates ⊣ | NEDD4L | 15328345 | SIGNOR-128429 |
| AMPK | phosphorylation up-regulates → | NEDD4L PSer795 | phosphorylation up-regulates → | NEDD4L | 21501591 | SIGNOR-276326 |
| SGK1 | phosphorylation up-regulates → | NEDD4L PSer448 | phosphorylation down-regulates ⊣ | NEDD4L | 15677482 | SIGNOR-133438 |
| SGK1 | phosphorylation up-regulates → | NEDD4L PThr383 | phosphorylation down-regulates ⊣ | NEDD4L | 12911626 | SIGNOR-263076 |
| AMPK | phosphorylation up-regulates → | NEDD4L PSer795 | phosphorylation up-regulates → | NEDD4L | 21501591 | SIGNOR-276324 |
| AMPK | phosphorylation up-regulates → | NEDD4L PSer795 | phosphorylation up-regulates → | NEDD4L | 21501591 | SIGNOR-277858 |
| SGK1 | phosphorylation up-regulates → | NEDD4L PSer342 | phosphorylation up-regulates → | NEDD4L | 11742982 | SIGNOR-113052 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| SGK3 | phosphorylation → down-regulates activity | NEDD4L | SIGNOR-280125 |
| SGK1 | phosphorylation → down-regulates activity | NEDD4L | SIGNOR-251949 |
| PRKACA | phosphorylation down-regulates | NEDD4L | SIGNOR-128429 |
| AMPK | phosphorylation → up-regulates activity | NEDD4L | SIGNOR-276326 |
| SGK1 | phosphorylation down-regulates | NEDD4L | SIGNOR-133438 |
| SGK1 | phosphorylation → down-regulates activity | NEDD4L | SIGNOR-263076 |
| AMPK | phosphorylation → up-regulates activity | NEDD4L | SIGNOR-276324 |
| AMPK | phosphorylation → up-regulates activity | NEDD4L | SIGNOR-277858 |
| SGK1 | phosphorylation → up-regulates | NEDD4L | SIGNOR-113052 |