Entity Details

Name NEK1
ID Q96PY6
Role kinase
Enzymatic Domains
Protein kinase 4-258
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
NEK1VDAC1Ser193DGTEFGGsIYQKVNKphosphorylation
down-regulates		20230784SIGNOR-164222
NEK1VHLSer168RCLQVVRsLVKPENYphosphorylation
down-regulates quantity by destabilization		23255108SIGNOR-276434
NEK1ME1Ser336KKIWLVDsKGLIVKGphosphorylation
down-regulates activity		31735643SIGNOR-275570
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
NEK1phosphorylation
up-regulates
→
VDAC1
PSer193		phosphorylation
down-regulates
⊣		VDAC120230784SIGNOR-164222
NEK1phosphorylation
up-regulates
→
VHL
PSer168		phosphorylation
down-regulates
⊣		VHL23255108SIGNOR-276434
NEK1phosphorylation
up-regulates
→
ME1
PSer336		phosphorylation
down-regulates
⊣		ME131735643SIGNOR-275570
Regulator Mechanism/Effect Target SIGNOR-ID
NEK1phosphorylation
img/direct_inhibition.png
down-regulates 		VDAC1SIGNOR-164222
NEK1phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		VHLSIGNOR-276434
NEK1phosphorylation
→
down-regulates activity 		ME1SIGNOR-275570