| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TLK1 | NEK1 | Thr141 | IFLTKDGtVQLGDFG | phosphorylation up-regulates activity | 31914854 | SIGNOR-279301 |
| TLK1 | NEK1 | Thr141 | IFLTKDGtVQLGDFG | phosphorylation up-regulates activity | 28426283 | SIGNOR-275840 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TLK1 | phosphorylation up-regulates → | NEK1 PThr141 | phosphorylation up-regulates → | NEK1 | 31914854 | SIGNOR-279301 |
| TLK1 | phosphorylation up-regulates → | NEK1 PThr141 | phosphorylation up-regulates → | NEK1 | 28426283 | SIGNOR-275840 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| TLK1 | phosphorylation → up-regulates activity | NEK1 | SIGNOR-279301 |
| TLK1 | phosphorylation → up-regulates activity | NEK1 | SIGNOR-275840 |