Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
SMG1	TP53	Ser15	PSVEPPLsQETFSDL	phosphorylation up-regulates	15175154	SIGNOR-125135
SMG1	UPF1	Ser1089	GLSQPELsQDSYLGD	phosphorylation up-regulates	23356578	SIGNOR-200785
SMG1	UPF1	Ser1107	SQIDVALsQDSTYQG	phosphorylation up-regulates	23356578	SIGNOR-200789
SMG1	UPF1	Thr28	AELLGADtQGSEFEF	phosphorylation up-regulates	23356578	SIGNOR-200793

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
SMG1	phosphorylation up-regulates →	TP53 PSer15	phosphorylation up-regulates →	TP53	15175154	SIGNOR-125135
SMG1	phosphorylation up-regulates →	UPF1 PSer1089	phosphorylation up-regulates →	UPF1	23356578	SIGNOR-200785
SMG1	phosphorylation up-regulates →	UPF1 PSer1107	phosphorylation up-regulates →	UPF1	23356578	SIGNOR-200789
SMG1	phosphorylation up-regulates →	UPF1 PThr28	phosphorylation up-regulates →	UPF1	23356578	SIGNOR-200793

Regulator	Mechanism/Effect	Target	SIGNOR-ID
SMG1	phosphorylation → up-regulates	TP53	SIGNOR-125135
SMG1	phosphorylation → up-regulates	UPF1	SIGNOR-200785
SMG1	phosphorylation → up-regulates	UPF1	SIGNOR-200789
SMG1	phosphorylation → up-regulates	UPF1	SIGNOR-200793