Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
AURKA	SPAG5	Ser115	ISSTPKTsEEAVDPL	phosphorylation up-regulates activity	25009111	SIGNOR-276648
GSK3B	SPAG5	Thr937	ADEEPEStPVPLLGS	phosphorylation up-regulates	18055457	SIGNOR-159582
GSK3B	SPAG5	Thr111	PIPQISStPKTSEEA	phosphorylation up-regulates	18055457	SIGNOR-159578
CDC14A	SPAG5	–		dephosphorylation down-regulates activity	27325694	SIGNOR-277066
PLK1	SPAG5	–		phosphorylation up-regulates activity	33288550	SIGNOR-279423
GSK3B	SPAG5	Ser974	EESLAEMsIMTTELQ	phosphorylation up-regulates	18055457	SIGNOR-159574
GSK3B	SPAG5	Thr978	AEMSIMTtELQSLCS	phosphorylation up-regulates	18055457	SIGNOR-159586

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
AURKA	phosphorylation up-regulates →	SPAG5 PSer115	phosphorylation up-regulates →	SPAG5	25009111	SIGNOR-276648
GSK3B	phosphorylation up-regulates →	SPAG5 PThr937	phosphorylation up-regulates →	SPAG5	18055457	SIGNOR-159582
GSK3B	phosphorylation up-regulates →	SPAG5 PThr111	phosphorylation up-regulates →	SPAG5	18055457	SIGNOR-159578
GSK3B	phosphorylation up-regulates →	SPAG5 PSer974	phosphorylation up-regulates →	SPAG5	18055457	SIGNOR-159574
GSK3B	phosphorylation up-regulates →	SPAG5 PThr978	phosphorylation up-regulates →	SPAG5	18055457	SIGNOR-159586

Regulator	Mechanism/Effect	Target	SIGNOR-ID
AURKA	phosphorylation → up-regulates activity	SPAG5	SIGNOR-276648
GSK3B	phosphorylation → up-regulates	SPAG5	SIGNOR-159582
GSK3B	phosphorylation → up-regulates	SPAG5	SIGNOR-159578
CDC14A	dephosphorylation → down-regulates activity	SPAG5	SIGNOR-277066
PLK1	phosphorylation → up-regulates activity	SPAG5	SIGNOR-279423
GSK3B	phosphorylation → up-regulates	SPAG5	SIGNOR-159574
GSK3B	phosphorylation → up-regulates	SPAG5	SIGNOR-159586