| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ERK1/2 | CIC | Ser1409 | SAPEDPTsPKRKMRR | phosphorylation down-regulates | 21087211 | SIGNOR-244630 |
| RPS6KA3 | CIC | Ser173 | PGKRRTQsLSALPKE | phosphorylation down-regulates | 21087211 | SIGNOR-169887 |
| Gbeta | CIC | – | phosphorylation down-regulates | 21087211 | SIGNOR-270090 | |
| RPS6K | CIC | Ser173 | PGKRRTQsLSALPKE | phosphorylation down-regulates | 21087211 | SIGNOR-252778 |
| MAPK3 | CIC | Ser1409 | SAPEDPTsPKRKMRR | phosphorylation down-regulates | 21087211 | SIGNOR-169879 |
| RPS6KA1 | CIC | Ser173 | PGKRRTQsLSALPKE | phosphorylation down-regulates | 21087211 | SIGNOR-169883 |
| MAPK1 | CIC | Ser1409 | SAPEDPTsPKRKMRR | phosphorylation down-regulates | 21087211 | SIGNOR-169875 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ERK1/2 | phosphorylation up-regulates → | CIC PSer1409 | phosphorylation down-regulates ⊣ | CIC | 21087211 | SIGNOR-244630 |
| RPS6KA3 | phosphorylation up-regulates → | CIC PSer173 | phosphorylation down-regulates ⊣ | CIC | 21087211 | SIGNOR-169887 |
| RPS6K | phosphorylation up-regulates → | CIC PSer173 | phosphorylation down-regulates ⊣ | CIC | 21087211 | SIGNOR-252778 |
| MAPK3 | phosphorylation up-regulates → | CIC PSer1409 | phosphorylation down-regulates ⊣ | CIC | 21087211 | SIGNOR-169879 |
| RPS6KA1 | phosphorylation up-regulates → | CIC PSer173 | phosphorylation down-regulates ⊣ | CIC | 21087211 | SIGNOR-169883 |
| MAPK1 | phosphorylation up-regulates → | CIC PSer1409 | phosphorylation down-regulates ⊣ | CIC | 21087211 | SIGNOR-169875 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ERK1/2 | phosphorylation down-regulates | CIC | SIGNOR-244630 |
| RPS6KA3 | phosphorylation down-regulates | CIC | SIGNOR-169887 |
| Gbeta | phosphorylation down-regulates | CIC | SIGNOR-270090 |
| RPS6K | phosphorylation down-regulates | CIC | SIGNOR-252778 |
| MAPK3 | phosphorylation down-regulates | CIC | SIGNOR-169879 |
| RPS6KA1 | phosphorylation down-regulates | CIC | SIGNOR-169883 |
| MAPK1 | phosphorylation down-regulates | CIC | SIGNOR-169875 |
