| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6KA1 | CIC | Ser173 | PGKRRTQsLSALPKE | phosphorylation down-regulates | 21087211 | SIGNOR-169883 |
| RPS6KA3 | CIC | Ser173 | PGKRRTQsLSALPKE | phosphorylation down-regulates | 21087211 | SIGNOR-169887 |
| RPS6K | CIC | Ser173 | PGKRRTQsLSALPKE | phosphorylation down-regulates | 21087211 | SIGNOR-252778 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6KA1 | phosphorylation up-regulates → | CIC PSer173 | phosphorylation down-regulates ⊣ | CIC | 21087211 | SIGNOR-169883 |
| RPS6KA3 | phosphorylation up-regulates → | CIC PSer173 | phosphorylation down-regulates ⊣ | CIC | 21087211 | SIGNOR-169887 |
| RPS6K | phosphorylation up-regulates → | CIC PSer173 | phosphorylation down-regulates ⊣ | CIC | 21087211 | SIGNOR-252778 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| RPS6KA1 | phosphorylation down-regulates | CIC | SIGNOR-169883 |
| RPS6KA3 | phosphorylation down-regulates | CIC | SIGNOR-169887 |
| RPS6K | phosphorylation down-regulates | CIC | SIGNOR-252778 |
