Entity Details

Name USP28
ID Q96RU2
Role substrate
Enzymatic Domains
UIM 97-116

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USP 162-650
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
ATRUSP28Ser714ESSTNSSsQDYSTSQphosphorylation
up-regulates activity		31938050SIGNOR-275851
ATMUSP28Ser714ESSTNSSsQDYSTSQphosphorylation
down-regulates activity		31938050SIGNOR-275853
ATMUSP28Ser67DERVKEPsQDTVATEphosphorylation
down-regulates activity		31938050SIGNOR-275852
ATRUSP28Ser67DERVKEPsQDTVATEphosphorylation
up-regulates activity		31938050SIGNOR-275850
ATMUSP28–phosphorylation
up-regulates activity		31938050SIGNOR-279007
ATMUSP28Ser495
View in OncoXplorer
STSTESSsQDVESTFphosphorylation
down-regulates activity		31938050SIGNOR-275854
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
ATRphosphorylation
up-regulates
→
USP28
PSer714		phosphorylation
up-regulates
→		USP2831938050SIGNOR-275851
ATMphosphorylation
up-regulates
→
USP28
PSer714		phosphorylation
down-regulates
⊣		USP2831938050SIGNOR-275853
ATMphosphorylation
up-regulates
→
USP28
PSer67		phosphorylation
down-regulates
⊣		USP2831938050SIGNOR-275852
ATRphosphorylation
up-regulates
→
USP28
PSer67		phosphorylation
up-regulates
→		USP2831938050SIGNOR-275850
ATMphosphorylation
up-regulates
→
USP28
PSer495		phosphorylation
down-regulates
⊣		USP2831938050SIGNOR-275854
Regulator Mechanism/Effect Target SIGNOR-ID
ATRphosphorylation
→
up-regulates activity 		USP28SIGNOR-275851
ATMphosphorylation
→
down-regulates activity 		USP28SIGNOR-275853
ATMphosphorylation
→
down-regulates activity 		USP28SIGNOR-275852
ATRphosphorylation
→
up-regulates activity 		USP28SIGNOR-275850
ATMphosphorylation
→
up-regulates activity 		USP28SIGNOR-279007
ATMphosphorylation
→
down-regulates activity 		USP28SIGNOR-275854