| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ATR | USP28 | Ser67 | DERVKEPsQDTVATE | phosphorylation up-regulates activity | 31938050 | SIGNOR-275850 |
| ATM | USP28 | Ser67 | DERVKEPsQDTVATE | phosphorylation down-regulates activity | 31938050 | SIGNOR-275852 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ATR | phosphorylation up-regulates → | USP28 PSer67 | phosphorylation up-regulates → | USP28 | 31938050 | SIGNOR-275850 |
| ATM | phosphorylation up-regulates → | USP28 PSer67 | phosphorylation down-regulates ⊣ | USP28 | 31938050 | SIGNOR-275852 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ATR | phosphorylation → up-regulates activity | USP28 | SIGNOR-275850 |
| ATM | phosphorylation → down-regulates activity | USP28 | SIGNOR-275852 |